Investigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced diabetes mellitus

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dc.contributor.authorComu, F. M.
dc.contributor.authorOzturk, L.
dc.contributor.authorAlkan, M.
dc.contributor.authorPampal, K.
dc.contributor.authorArslan, M.
dc.contributor.authorIsik, B.
dc.contributor.authorYilmaz, D.
dc.date.accessioned2020-06-25T18:12:26Z
dc.date.available2020-06-25T18:12:26Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063; PAMPAL, HASAN KUTLUK/0000-0003-4664-391X; Comu, Faruk Metin/0000-0002-1106-0741
dc.description.abstractPurpose: In the current study we aim to investigate the effects of vitamin C and profol on red blood cell deformability in diabetic rats Materials and methods: Twenty- eight Wistar Albino rats were included in the study after streptozocin (60 mg/kg) treatment for 4 weeks of observation for diabetes presence. Twenty-eight rats were allocated to 4 groups. In group DP (n = 7) 150 mg.kg(-1) of propofol was injected intraperitoneally. In group DP-vit C (n = 7) rats 100 mg/kg of vitamin C (Ascorbic acid, Redoxon (R) 1000 mg/5 mL - Roche) were applied one hour before administrating 150 mg.kg(-1) of propofol, while rats in control group (n = 7), and diabetic control group (n = 7) received intraperitoneally physiological saline. Deformability measurements were achieved by using erythrocyte suspensions with hematocrit level of 5 % in PBS buffer. Results: Erythrocyte deformability was significantly higher in diabetic control group than in control and vitamin C plus propofol groups (p = 0.00, p = 0.025, respectively). Erythrocyte deformability indexes were found similar in control group and vitamin C plus propofol group (p = 0.949). Relative resistance was increased in diabetic rat model. Conclusions: Erythrocyte deformability was damaged in rats with diabetes. This injury might lead to further problems in microcirculation. Application of propofol did not alter red cell deformability in diabetic rats. Vitamin C supplementation seems to reverse those negative effects and variations in erythrocyte deformability (Fig. 2, Ref. 57). Text in PDF www.elis.sk.en_US
dc.identifier.citationÇomu, F. M. vb. (2014).Investigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced diabetes mellitus. Bratislava Medical Journal.115(7),400-404.en_US
dc.identifier.doi10.4149/BLL_2014_0079
dc.identifier.endpage404en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue7en_US
dc.identifier.pmid25077361
dc.identifier.scopus2-s2.0-84905991410
dc.identifier.scopusqualityQ2
dc.identifier.startpage400en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_0079
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5912
dc.identifier.volume115en_US
dc.identifier.wosWOS:000340863400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectpropofol experimental diabeten_US
dc.subjectvitamin Cen_US
dc.subjectraten_US
dc.titleInvestigation of the effects of propofol and vitamin C administration on erythrocyte deformability in rats with streptozotocin-induced diabetes mellitusen_US
dc.typeArticle

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