Release characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beads

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dc.contributor.authorŞanlı, Oya
dc.contributor.authorAy, Nuran
dc.contributor.authorIsıklan, Nuran
dc.date.accessioned2020-06-25T17:43:59Z
dc.date.available2020-06-25T17:43:59Z
dc.date.issued2007
dc.description.abstractIn this study, acrylamide (AAm) was grafted onto poly(vinyl alcohol) (PVA) with UV radiation at ambient temperature. The graft copolymer (PVA-g-PAAm) was characterized by using Fourier transform infrared spectroscopy (FTIR), elemental analysis and differential scanning calorimetry (DSC). Polymeric blend beads of PVA-g-PAAm and PVA with sodium alginate (NaAlg) were prepared by cross-linking with glutaraldehyde (GA) and used to deliver a model anti-inflammatory drug, diclofenac sodium (DS). Preparation condition of the beads was optimized by considering the percentage entrapment efficiency, particle size, swelling capacity of beads and their release data. Effects of variables such as PVA/NaAlg ratio, acrylamide content, exposure time to GA and drug/polymer ratio on the release of DS were discussed at three different pH values (1.2, 6.8, 7.4). It was observed that, DS release from the beads decreased with increasing PVA/NaAlg (m/m) ratio, drug/polymer ratio (d/p) and extent of cross-linking. However, DS release increased with increasing acrylamide content of the PVA-g-PAAm polymer. The highest DS release was obtained to be 92% for 1/1 PVA-g-PAAm/NaAlg ratio beads. It was also observed from release results that DS release from the beads through the external medium is much higher at high pH (6.8 and 7.4) than that at low pH (1.2). The drug release from the beads mostly followed Case 11 transport. (c) 2006 Elsevier B.V. All rights reserved.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ejpb.2006.08.004
dc.identifier.endpage214en_US
dc.identifier.issn0939-6411
dc.identifier.issn1873-3441
dc.identifier.issue2en_US
dc.identifier.pmid16996255
dc.identifier.scopus2-s2.0-33846025999
dc.identifier.scopusqualityQ1
dc.identifier.startpage204en_US
dc.identifier.urihttps://doi.org10.1016/j.ejpb.2006.08.004
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3974
dc.identifier.volume65en_US
dc.identifier.wosWOS:000244073500007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal Of Pharmaceutics And Biopharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgraft copolymeren_US
dc.subjectcontrolled releaseen_US
dc.subjectdrug delivery systemsen_US
dc.subjectdiclofenac sodiumen_US
dc.subjecthydrophilic polymersen_US
dc.titleRelease characteristics of diclofenac sodium from poly(vinyl alcohol)/sodium alginate and poly(vinyl alcohol)-grafted-poly(acrylamide)/sodium alginate blend beadsen_US
dc.typeArticle

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