Microwave-induced synthesis of alginate-graft-poly(N-isopropylacrylamide) and drug release properties of dual pH- and temperature-responsive beads

Basit Öğe Kaydı
dc.contributor.authorIsiklan, Nuran
dc.contributor.authorKucukbalci, Gulcan
dc.date.accessioned2020-06-25T17:52:36Z
dc.date.available2020-06-25T17:52:36Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe first decade of the 21st century saw an increasing interest in the development of devices and biomaterials for delivery of bioactive substances that can be controlled by external stimuli. This study deals with the production of novel pH and temperature responsive beads for colon-specific delivery of indomethacine (IM). For this purpose, N-isopropylacrylamide (NIPAAm) was grafted onto sodium alginate (NaAlg) with microwave radiation in aqueous solution. The graft copolymer (NaAlg-g-PNIPAAm) was characterized by using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), elemental analysis, differential scanning calorimetry (DSC), and thermogravimetric analysis. A series of pH- and temperature-responsive NaAlg-g-PNIPAAm beads were prepared as drug delivery matrices of indomethacine cross-linked by glutaraldehyde (GA) in the hydrochloric acid catalyst. Preparation condition of the beads was optimized by considering the percentage entrapment efficiency, particle size, swelling capacity of beads, and their release data. Effects of variables such as graft yield, drug/polymer ratio, exposure time to GA, and concentration of GA on the release of IM were investigated and discussed at two different pH values (1.2 and 7.4) and temperatures (25 degrees C and 37 degrees C). It was observed that IM release from the beads decreased when the grafting of NIPAAm, drug/polymer ratio (d/p), and extent of cross-linking were increased. The results also showed that NaAlg-g-PIPAAm beads were positive pH and temperature responsive. The release of IM from grafted beads was slower for the pH 1.2 solution than that of the pH 7.4 buffer solution, whereas the release rate was higher at 37 degrees C than at 25 degrees C. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [210T149]en_US
dc.description.sponsorshipThe authors are grateful to the TUBITAK for financial support with the Project Number of 210T149.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ejpb.2012.07.015
dc.identifier.endpage331en_US
dc.identifier.issn0939-6411
dc.identifier.issue2en_US
dc.identifier.pmid22906708
dc.identifier.scopus2-s2.0-84867870780
dc.identifier.scopusqualityQ1
dc.identifier.startpage316en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejpb.2012.07.015
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5189
dc.identifier.volume82en_US
dc.identifier.wosWOS:000312043300011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Pharmaceutics And Biopharmaceutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGraft copolymeren_US
dc.subjectControlled releaseen_US
dc.subjectDrug delivery systemsen_US
dc.subjectIndomethacinen_US
dc.subjectHydrophilic polymersen_US
dc.titleMicrowave-induced synthesis of alginate-graft-poly(N-isopropylacrylamide) and drug release properties of dual pH- and temperature-responsive beadsen_US
dc.typeArticle

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