The role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowth

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dc.contributor.authorGürsoy, Ulvi Kahraman
dc.contributor.authorSokucu, Oral
dc.contributor.authorUitto, Veli-Jukka
dc.contributor.authorAydin, Ahmet
dc.contributor.authorDemirer, Serhat
dc.contributor.authorToker, Hülya
dc.contributor.authorSayal, Ahmet
dc.date.accessioned2020-06-25T17:43:35Z
dc.date.available2020-06-25T17:43:35Z
dc.date.issued2007
dc.descriptionGursoy, Ulvi Kahraman/0000-0002-1225-5751
dc.description.abstractThe aim of this study was to investigate the role of nickel in orthodontic treatment-induced gingival hyperplasia. The nickel concentration in gingival tissues with and without overgrowth, histopathology of gingival overgrowths, and epithelial cell proliferation response to different nickel concentrations were analysed. Ten patients receiving orthodontic therapy (eight females and two males, mean age 15.4 years) were included in the study. Hyperplastic and healthy gingiva samples were collected from the same patients. The amount of nickel in the gingival tissue samples was analysed using the atomic absorption spectrometry technique. The tissues removed from hyperplastic areas during gingivectomy were also used for histological analysis. To analyse the effect of nickel on epithelial cell proliferation, four different nickel concentrations (0.5, 2, 5, and 10 mu g) were incubated with keratinocyte cells for 11 days. Mann-Whitney U-test, analysis of variance, and Tukey's test were used in the statistical analyses. The results did not show any difference in nickel concentration between the study and control gingiva tissue samples, but histological analysis demonstrated an increase in epithelial thickness and a significant increase (P = 0.031, 0.02, 0.02) in epithelial cell proliferation in response to low-dose nickel concentrations, with a toxic response to a higher dose. In the limitations of this study, it is plausible that the effect of a continuing low-dose nickel release to epithelium is the initiating factor of gingival overgrowth induced by orthodontic treatment.en_US
dc.identifier.citationGursoy, U. K., Sokucu, O., Uitto, V. J., Aydin, A., Demirer, S., Toker, H., Erdem, O., & Sayal, A. (2007). The role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowth. European journal of orthodontics, 29(6), 555–558. https://doi.org/10.1093/ejo/cjm074en_US
dc.identifier.doi10.1093/ejo/cjm074
dc.identifier.endpage558en_US
dc.identifier.issn0141-5387
dc.identifier.issue6en_US
dc.identifier.pmid17989122
dc.identifier.scopus2-s2.0-36949015179
dc.identifier.scopusqualityQ1
dc.identifier.startpage555en_US
dc.identifier.urihttps://doi.org10.1093/ejo/cjm074
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3807
dc.identifier.volume29en_US
dc.identifier.wosWOS:000251506100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofEuropean Journal Of Orthodontics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowthen_US
dc.typeArticle

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