Why do multiple sclerosis and migraine coexist?

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dc.contributor.authorHamamci, Mehmet
dc.contributor.authorGocmen, Ayse Yesim
dc.contributor.authorSay, Bahar
dc.contributor.authorAlpua, Murat
dc.contributor.authorBadem, Nermin Dindar
dc.contributor.authorErgun, Ufuk
dc.contributor.authorInan, Levent Ertugrul
dc.date.accessioned2021-01-14T18:10:41Z
dc.date.available2021-01-14T18:10:41Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionHamamci, Mehmet/0000-0001-7100-3952; alpua, murat/0000-0002-0951-5962
dc.description.abstractBackground: Migraine coexistence, which is high in multiple sclerosis (MS), is reported. To better understand the etiology of the coexistence of MS and migraine and the outcomes of this relationship, the vitamin D, vitamin D-binding protein (VITDBP), vitamin D receptor (VITDR), high-sensitivity C-reactive protein (hs-CRP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), total antioxidant status (TAS), total oxidant status (TOS), and Oxidative Stress Index (OSI) values were examined in patients with the coexistence of relapsing-remitting multiple sclerosis (RRMS) and migraine. Methods: This study was conducted between January 1, 2019, and July 25, 2019, at the neurology and biochemistry clinics of two different tertiary hospitals simultaneously. Overall, 50 RRMS patients with migraine, 50 RRMS patients without migraine, and 50 healthy volunteers were included in the study. The participants' vitamin D, VITDBP, VITDR, hs-CRP, SOD, CAT, GSH-Px, TAS, TOS, and OSI values were measured. Results: The vitamin D and VITDR values of the RRMS patients with migraine were lower than those of the RRMS patients without migraine (respectively, p = 0.014, p < 0.001). There was no significant difference between the RRMS patients with and without migraine in terms of their VITDBP values (p = 0.570). The SOD, CAT, GSH-Px, and TAS values of the RRMS patients with migraine were lower than those without migraine (all p < 0.001). The hs-CRP and TOS values of the RRMS patients with migraine were higher than those without migraine (all p < 0.001). Conclusion: To the best of our knowledge, this is the first study on this topic to date. Based on the results, our study may shed light on the etiopathogenesis of the coexistence of MS and migraine and new treatments. However, more studies are needed to better understand the etiology of this relationship and its negative effects.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1016/j.msard.2020.101946
dc.identifier.issn2211-0348
dc.identifier.issn2211-0356
dc.identifier.pmid31982663
dc.identifier.scopus2-s2.0-85078150415
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.msard.2020.101946
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12727
dc.identifier.volume40en_US
dc.identifier.wosWOS:000528173100022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofMULTIPLE SCLEROSIS AND RELATED DISORDERS
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectComorbidityen_US
dc.subjectVitamin Den_US
dc.subjectHigh-sensitivity C-reactive proteinen_US
dc.subjectOxidative stressen_US
dc.subjectRelationshipen_US
dc.titleWhy do multiple sclerosis and migraine coexist?en_US
dc.typeArticle

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