Investigation of Effects of Propofol and Vitamin C Administration on Hepatic and Renal Tissue in Diabetic Rats

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dc.contributor.authorArslan, Mustafa
dc.contributor.authorBilge, Mustafa
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorOzturk, Levent
dc.contributor.authorIsik, Berrin
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorYilmaz, Dervis
dc.date.accessioned2020-06-25T18:15:56Z
dc.date.available2020-06-25T18:15:56Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractObective: A close relationship between diabetic complications and lipid peroxidation is known. It was shown that in diabetic rat pharmacodynamics and pharmacokinetics of propofol was changed. We aim to investigate effects of application propofol and vitamin C on liver and kidney tissue in diabetic rats. Method: Twenty eight wistar albino rats were randomly divided into 4 study groups. Rats in control group were treated only with saline intra peritonealy. Experimental diabetes was induced with a single dose of streptozotocin (60 mg/kg). In propofol adminastrated diabetic rat group (DP) 150 mg/kg propofol was given intraperitoneally. In both propofol and vitamin C adminastrated rats group (DP+Vit C), 100 mg/kg vitamin C was given before 30 minutes administration of 150 mg/kg propofol. In the diabetic control group (DC) administartion of intraperitoneally saline solution alone to the diabetic rats was achieved. Rats were sacrified and liver and kidney tissue were removed. Liver and renal tissue was obtained for histological and biochemical determination. Antioxidant enzymes SOD, CAT, GST activities and MDA concentration were determined in liver and renal tissue. Results: Liver MDA levels in group DC was found to be significantly higher than DP, DP+Vit C and C groups (p=0.024, p=0.008, p=0.016). Liver SOD activity in group 3 was found to be significantly lower in groups DP+Vit C and C (p=0.011, p=0.038). Liver GST activity in group DP+Vit C was found to be significantly lower when compared with group C (p = 0.011). Liver CAT activity showed no difference among groups. Renal MDA levels in group DC was found to be significantly higher in groups DP+Vit C and C (p=0.016, p=0.010). Renal SOD activity in DC was found to be significantly lower than groups DP, DP+Vit C and C (p=0.028, p=0.019, p=0.009). Renal GST and CAT activity showed no difference among groups. Histopathalogically group DP was more damaged than in group C. Conclusion: Diabetes increased lipid peroxidation and reduced the antioxidant activity. However, application of vitamin C reduced lipid peroxidation and increased antioxidant activity. Results of our study have to be supported other experimental studies.en_US
dc.identifier.citationArslan M., Bilge M., Sezen Ş. C., Öztürk L., Işık B., Çomu F. M., Alkan M., Ataç M. S., Kavutcu M., Yılmaz D. (2015). Diyabetik Ratlarda Propofol ve C Vitamini Uygulamasının Karaciğer ve Böbrek Dokusu Üzerindeki Etkisinin Araştırılması. Gazi Medical Journal, 26(3), 101 - 106.en_US
dc.identifier.doi10.12996/gmj.2015.31
dc.identifier.endpage106en_US
dc.identifier.issn2147-2092
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84936883751
dc.identifier.scopusqualityQ4
dc.identifier.startpage101en_US
dc.identifier.trdizinidtrdizinikyoktur
dc.identifier.urihttps://doi.org/10.12996/gmj.2015.31
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6352
dc.identifier.volume26en_US
dc.identifier.wosWOS:000217477300007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherGazi Univ, Fac Meden_US
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectpropofolen_US
dc.subjectvitamin Cen_US
dc.subjectraten_US
dc.subjectliveren_US
dc.subjectkidneyen_US
dc.subjectantioxidant systemen_US
dc.titleInvestigation of Effects of Propofol and Vitamin C Administration on Hepatic and Renal Tissue in Diabetic Ratsen_US
dc.typeArticle

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