Evaluation of erythrocyte deformability in experimentally induced osteoporosis in female rats and the effects of vitamin C supplementation on erythrocyte deformability

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dc.contributor.authorArslan, Ayşe
dc.contributor.authorAydin, Gülümser
dc.contributor.authorKeleş, İlayda
dc.contributor.authorÇomu, Faruk Metin
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2020-06-25T17:52:12Z
dc.date.available2020-06-25T17:52:12Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractObjective: The aim of this study was to evaluate the possible variations in antioxidant enzymes, lipid peroxidation and erythrocyte deformability in experimentally induced osteoporosis in female rats and to assess the effects of vitamin C supplementation on those variations. Material: A total of 20 female Wistar Albino Rats were randomized into the three groups as controls (Group C, n=6), ovariectomized rats (Group 0, n=7) and ovariectomized rats receiving vitamin C supplementation (Group OVC, n=7). After the surgical procedure of ovariectomy, group OVC received 1 g ascorbic acid in 500mL water daily. After 100 days following the ovariectomy, bone mineral density (BMD) was measured by using dual-energy X-ray absorptiometry. Results: BMD was significantly lower in the group 0 than in the group C (p=0.015), whereas it was significantly higher in the group OVC than in the group 0 (p=0.003). MDA activity was significantly higher in the group 0 than in the group C (p=0.032), whereas it was significantly lower in the group OVC than in the group 0 (p=0.025). SOD activity was significantly higher in the group 0 than in the group C (p=0.032). Erythrocyte deformability was significantly higher in the group 0 than in the group C and OVC (p=0.008, p=0.021, respectively). Conclusion: Erythrocyte deformability may show negative variations, suggesting a causative role in disruption of blood flow and tissue perfusion, which also negatively affect bone metabolism. Vitamin C supplementation seems to reverse those negative effects of variations in erythrocyte deformability. However, our preliminary results should be confirmed in more experimental studies and clinical trials (Tab. 3, Ref. 28). Full Text in free PDF www.bmj.sk.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage609en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue11en_US
dc.identifier.pmid22180984
dc.identifier.scopus2-s2.0-82055175191
dc.identifier.scopusqualityQ2
dc.identifier.startpage605en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5104
dc.identifier.volume112en_US
dc.identifier.wosWOS:000296929900002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectosteoporosisen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectmalondialdehydeen_US
dc.titleEvaluation of erythrocyte deformability in experimentally induced osteoporosis in female rats and the effects of vitamin C supplementation on erythrocyte deformabilityen_US
dc.typeArticle

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