Synthesis and characterization of antibacterial drug loaded beta-tricalcium phosphate powders for bone engineering applications

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dc.contributor.authorTopsakal, Aysenur
dc.contributor.authorEkren, Nazmi
dc.contributor.authorKilic, Osman
dc.contributor.authorOktar, Faik N.
dc.contributor.authorMahirogullari, Mahir
dc.contributor.authorOzkan, Ozan
dc.contributor.authorSasmazel, Hilal Turkoglu
dc.date.accessioned2021-01-14T18:10:55Z
dc.date.available2021-01-14T18:10:55Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionStan, George E./0000-0003-0289-8988; Gunduz, Oguzhan/0000-0002-9427-7574; Chirica, Maria Iuliana/0000-0003-4698-9857; Kilic, Osman/0000-0002-4560-5527
dc.description.abstractPowders of beta-tricalcium phosphate [beta-TCP, beta-Ca-3(PO4)(2)] and composite powders of beta-TCP and polyvinyl alcohol (PVA) were synthesized by using wet precipitation methods. First, the conditions for the preparation of single phase beta-TCP have been delineated. In the co-precipitation procedure, calcium nitrate and diammonium hydrogen phosphate were used as calcium and phosphorous precursors, respectively. The pH of the system was varied in the range 7-11 by adding designed amounts of ammonia solution. The filtered cakes were desiccated at 80 degrees C and subsequently calcined at different temperatures in the range between 700-1100 degrees C. Later on, rifampicin form II was used to produce drug-loaded beta-TCP and PVA/beta-TCP powders. All the synthesized materials have been characterized from morphological (by scanning electron microscopy) and structural-chemical (by X-ray diffraction and Fourier transform infrared spectroscopy) point of view. The drug loading capacity of the selected pure beta-TCP powder has been assessed. The biological performance (cytocompatibility in fibroblast cell culture and antibacterial efficacy against Escherichia coli and Staphylococcus aureus) has been tested with promising results. Application perspectives of the designed drug-bioceramic-polymer blends are advanced and discussed. [GRAPHICS] .en_US
dc.description.sponsorshipRomanian Ministry of Research and Innovation, CCCDI-UEFISCDI [PN-III-P1-1.2-PCCDI-2017-0062, 58, 2]en_US
dc.description.sponsorshipG.E.S. and I.M.B acknowledge the support of Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, in the framework of project PN-III-P1-1.2-PCCDI-2017-0062 (contract no. 58)/component project no. 2.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1007/s10856-019-6356-1
dc.identifier.issn0957-4530
dc.identifier.issn1573-4838
dc.identifier.issue2en_US
dc.identifier.pmid31965360
dc.identifier.scopus2-s2.0-85078310760
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s10856-019-6356-1
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12820
dc.identifier.volume31en_US
dc.identifier.wosWOS:000513866000006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSynthesis and characterization of antibacterial drug loaded beta-tricalcium phosphate powders for bone engineering applicationsen_US
dc.typeArticle

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