The relationship between adiponectin levels and proinflammatory cytokines and left ventricular mass in dialysis patients

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dc.contributor.authorEbinc, Fatma Ayerden
dc.contributor.authorEbinc, Haksun
dc.contributor.authorDerici, Ülver
dc.contributor.authorAral, Arzu
dc.contributor.authorAybay, Cemalettin
dc.contributor.authorTacoy, Gülten
dc.contributor.authorSindel, Şükrü
dc.date.accessioned2020-06-25T17:48:35Z
dc.date.available2020-06-25T17:48:35Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIntroduction: Adiponectin is increased in end-stage renal disease. However, efforts to clarify the cause of that increase and its clinical effects have been inconclusive. The aim of this study was to compare serum adiponectin levels of dialysis patients against healthy individuals and evaluate the relationship among adiponectin levels, IL-6, TNF-alpha and left ventricular mass index (LVMI). Methods: Adiponectin, IL-6 and TNF-a measurements and echocardiographic evaluations were performed in 36 hemodialysis, 30 continuous ambulatory peritoneal dialysis (CAPD) patients and 22 healthy volunteers. Adiponectin, IL-6 and TNF-alpha levels were measured by ELISA. Results: Adiponectin was found to be higher in hemodialysis (52.78 +/- 18.01 ng/mL) and CAPD (52.96 +/- 17.53 ng/mL) groups than controls (28.36 +/- 13.20 ng/ mL; p = 0.0003, p = 0.0003, respectively). No difference was observed between the hemodialysis and CAPD groups. Adiponectin was positively correlated with IL-6 (r = 0.293, p = 0.02), TNF-alpha (r = 0.458, p = 0.0003) and LVMI (r = 0.283, p = 0.02). In the partial correlation analysis, by controlling for body mass index, the correlation between adiponectin and TNF-alpha (r = 0.466, p = 0.0003) persisted. When IL- 6 was controlled with TNF- a, the relation between adiponectin and LVMI disappeared (r = 0.145, p = 0.30). In the linear regression analysis, with adiponectin as the dependent variable, and IL-6, TNF-alpha and body mass index as independent variables, a significant relationship was found between adiponectin and TNF-alpha (beta = 0.488, p = 0.001). Conclusions: Increased adiponectin seems to be associated with increased proinflammatory cytokines in dialysis patients, and this relationship suggests adiponectin may have a role in the development of left ventricular hypertrophy.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage223en_US
dc.identifier.issn1121-8428
dc.identifier.issn1724-6059
dc.identifier.issue2en_US
dc.identifier.pmid19384839
dc.identifier.scopus2-s2.0-67649409338
dc.identifier.scopusqualityQ1
dc.identifier.startpage216en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4501
dc.identifier.volume22en_US
dc.identifier.wosWOS:000269100900007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal Of Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdiponectinen_US
dc.subjectDialysis patientsen_US
dc.subjectEchocardiographyen_US
dc.subjectInflammatory cytokineen_US
dc.titleThe relationship between adiponectin levels and proinflammatory cytokines and left ventricular mass in dialysis patientsen_US
dc.typeArticle

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