Allergic and non-allergic asthma phenotypes and exposure to air pollution

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dc.authoridPEKINCE, BUSRA/0000-0001-7525-7896
dc.contributor.authorPekince, Busra
dc.contributor.authorBaccioglu, Ayse
dc.date.accessioned2025-01-21T16:35:31Z
dc.date.available2025-01-21T16:35:31Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective Although harmful effects of air pollution on airway diseases are well-established, its effect on allergy still remains unclear. The aim of this study was to examine changes on asthma clinic and oxidant homeostasis due to air pollution between allergic asthma (AA) and non-allergic asthma (NA) phenotypes. Methods This prospective, case-control study included patients with well-controlled asthma under regular treatment (n = 57) and healthy individuals (n = 51). Of asthma patients, 22 had AA and 35 had NA phenotypes. Respiratory symptoms, pulmonary function tests, serum total antioxidant status (TAS) and total oxidant status (TOS), and thiol/disulfide levels were compared between the most (V-1) and least (V-2) air-polluted times. Results High air pollution exposure resulted to an increase in the frequency of respiratory symptoms and serum inflammation markers in both asthmatic and healthy individuals. Frequency of dyspnea and cough in AA and rhinitis in NA decreased from V-1 to V-2. Hospitalization due to asthma exacerbation, systemic corticosteroid use, and eosinophil counts were more frequent in NA group than AA in V1. An increase of blood eosinophil counts was observed in AA group at the same visit. Mean TAS and TOS levels were higher in asthma group than control group, and the decline in TAS and TOS levels from V-1 to V-2 was seen only in NA. All thiols decreased and SH/total SH ratios significantly increased from V-1 to V-2 in all groups. Conclusion This study demonstrates that air pollution affects both asthma patients and healthy individuals. Through oxidant-antioxidant and thiol pathways, however, it adversely affects respiratory system of asthma patients, at a greater extent, than healthy individuals.
dc.description.sponsorshipKirikkale University, Scientific Research Project Center (BAP) [2018/026]
dc.description.sponsorshipThis study was supported by a grant from Kirikkale University, Scientific Research Project Center (BAP no:2018/026).
dc.identifier.doi10.1080/02770903.2021.1955133
dc.identifier.endpage1520
dc.identifier.issn0277-0903
dc.identifier.issn1532-4303
dc.identifier.issue8
dc.identifier.pmid34254843
dc.identifier.scopus2-s2.0-85111390557
dc.identifier.scopusqualityQ2
dc.identifier.startpage1509
dc.identifier.urihttps://doi.org/10.1080/02770903.2021.1955133
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24149
dc.identifier.volume59
dc.identifier.wosWOS:000675769900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Asthma
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAllergy; asthma; air pollution; environmental exposure; non-allergic
dc.titleAllergic and non-allergic asthma phenotypes and exposure to air pollution
dc.typeArticle

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