Does serum leptin levels differ between patients with rhinitis of allergic versus nonallergic aetiology?

Basit Öğe Kaydı
dc.authoridKALPAKLIOGLU, AYSE FUSUN/0000-0002-6548-6932
dc.authoridYalim, Sumeyra Alan/0000-0001-5986-0513
dc.contributor.authorKalpaklioglu, Ayse Fusun
dc.contributor.authorBaccioglu, Ayse
dc.contributor.authorYalim, Sumeyra Alan
dc.date.accessioned2025-01-21T16:37:48Z
dc.date.available2025-01-21T16:37:48Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Leptin may play a critical role in airway inflammation. However, it has rarely been evaluated in rhinitis with different aetiology. This study aimed to compare the serum leptin levels between allergic rhinitis (AR) and nonallergic rhinitis (NAR). Methods Patients with chronic rhinitis were classified due to skin prick (ALK-Abello/Madrid) and/or serum-specific immunoglobulin E tests (UniCAP 100-Pharmacia), against to aeroallergens if concordant with symptoms. Results A total of 398 patients with a mean age of 29.03 years were recruited and grouped as AR and NAR. Mean serum leptin levels were similar in patients with NAR and AR, as well as in patients with and without asthma, but were significantly higher in females than males in both groups. Also, leptin levels were significantly higher in obese than nonobese patients in AR. In correlation analysis, leptin levels were found to be correlated with female gender, older age, and high body mass index (BMI) in the whole group. Despite the higher total nasal symptom score (TNSS) in patients with AR compared with NAR, there was no association of leptin levels with TNSS, severity and seasonality of symptoms, and allergen sensitization. In logistic regression analysis, younger age and high serum leptin levels were found to be independent predictors for the diagnosis of AR. Conclusions We conclude that female patients with high BMI are more prone to AR probably due to immunological effects of adipose tissue, in addition to hormonal factors. This study showed that leptin measurement has limited value as a sole diagnostic tool to differentiate AR and NAR.
dc.identifier.doi10.1111/crj.13440
dc.identifier.endpage1358
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue12
dc.identifier.pmid34432379
dc.identifier.scopus2-s2.0-85114368264
dc.identifier.scopusqualityQ3
dc.identifier.startpage1352
dc.identifier.urihttps://doi.org/10.1111/crj.13440
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24541
dc.identifier.volume15
dc.identifier.wosWOS:000693649600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical Respiratory Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectallergic rhinitis; asthma; leptin; nonallergic rhinitis; obesity
dc.titleDoes serum leptin levels differ between patients with rhinitis of allergic versus nonallergic aetiology?
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu