Sanguisorba minor subsp. Balearica inhibit production of cytokines in a chronic model of inflammation induced by complete Freund's adjuvant
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Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Rheumatoid arthritis is an idiopathic auto-immune disease characterized destruction of cartilage and synovial membrane. TNF-alpha, IL-12 and IL-1 are well known inflammatory mediators of “rheumatoid arthritis”. These cytokines activate synoviocytes and chondrocytes and this results in the secretion of matrix metalloproteinase into the synovial fluid. Analgesic and anti-inflammatory drugs are used to suppress the symptoms. However, all these have several side effects. New therapies targeting the underlying immune process have been proposed. Recent research aims to discover long-acting anti-inflammatory drugs with minimal side effects. Sanguisorba minor subsp. Balearica (Smb) is known as a medicinal plant and has been used for treatment of various disorders. The usage of Smb for relieving of inflammation is noteworthy. This study aims to invastigate possible cytokine mediated anti-inflammatory effects of (Smb) on arthritic rats
Açıklama
55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions -- SEP 08-11, 2019 -- Helsinki, FINLAND
Anahtar Kelimeler
Kaynak
Toxicology Letters
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
314
Sayı
Künye
closedAccess
