Sanguisorba minor subsp. Balearica inhibit production of cytokines in a chronic model of inflammation induced by complete Freund's adjuvant

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dc.contributor.authorGenc, A. I.
dc.contributor.authorAdali, O.
dc.contributor.authorKul, O.
dc.contributor.authorOzkan, A. M. Gencler
dc.date.accessioned2020-06-25T18:30:29Z
dc.date.available2020-06-25T18:30:29Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description55th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions -- SEP 08-11, 2019 -- Helsinki, FINLAND
dc.description.abstractRheumatoid arthritis is an idiopathic auto-immune disease characterized destruction of cartilage and synovial membrane. TNF-alpha, IL-12 and IL-1 are well known inflammatory mediators of “rheumatoid arthritis”. These cytokines activate synoviocytes and chondrocytes and this results in the secretion of matrix metalloproteinase into the synovial fluid. Analgesic and anti-inflammatory drugs are used to suppress the symptoms. However, all these have several side effects. New therapies targeting the underlying immune process have been proposed. Recent research aims to discover long-acting anti-inflammatory drugs with minimal side effects. Sanguisorba minor subsp. Balearica (Smb) is known as a medicinal plant and has been used for treatment of various disorders. The usage of Smb for relieving of inflammation is noteworthy. This study aims to invastigate possible cytokine mediated anti-inflammatory effects of (Smb) on arthritic ratsen_US
dc.description.sponsorshipEuropean Soc Toxicol, Finnish Soc Toxicol, Charles River Co, Citoxlab, E R B C, Covance, ECELOC, ILSI Europe, Instem, Syngene, Wuki AppTec, Charles River, Elsevier, SafeNano, MatTek, Sanofi, Sysmex, RISE, ToxMinds, Admescope, Biobide, Chem Watch, D2team, European Food Safety Author, Epicurus, Eutoxrisk, Finnish Food Author, HSL HRT, RCC, Soc Toxicol, Team Masteryen_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpageS180en_US
dc.identifier.issn0378-4274
dc.identifier.issn1879-3169
dc.identifier.startpageS180en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7657
dc.identifier.volume314en_US
dc.identifier.wosWOS:000484771800484
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofToxicology Letters
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSanguisorba minor subsp. Balearica inhibit production of cytokines in a chronic model of inflammation induced by complete Freund's adjuvanten_US
dc.typeConference Object

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