Methylation and cancer: Review

Basit Öğe Kaydı
dc.contributor.authorSayin, Derya Beyza
dc.date.accessioned2020-06-25T17:44:28Z
dc.date.available2020-06-25T17:44:28Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractDNA methylation is the major epigenetic modification in mammals, and is seen in CpG dinucleotides. In normal cells, the CpG dinucleotides in repetitive DNA are methylated, and CpG islands, which are found in the promotor region in 50% of genes, are demethylated. Epigenetic modifications may be defined as inheritable gene expression changes, without altering the primary sequence of DNA. It is well established that epigenetic modifications are as important as genetic changes in cancer development. Cancer cells show genomic hypomethylation and gene promotor hypermethylation. Both are independent from each other, but are effective in cancerogenesis in different ways. Hypermethylation of the promotor has a supressive effect on the downstream gene, and is important in turnout supressor gene inactivation. hMLH1 and O-6-MGMT gene methylations are the most studied among different cancer types. Knudson's two hit hypothesis is the most common hypotesis for cancer development, and one of these hits may be epigenetic. Genomewide hypomethylation may favor for genomic instability and reactivation of parasitic sequences. Promotor hypermethylation may show different patterns in different cancers, or different types of the same cancer, and methylation patterns may be useful as a cancer biomarker or a prognostic marker. Epigenetic mutations are reversible, and there is sparse promotor hypermethylation in normal cells, which makes demethylating agents highly specific for cancer cells. Increasing our knowledge on the methylation changes in cancer cells will improve our approaches to the treatment, diagnosis and prevention of cancer.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage524en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-47749097550
dc.identifier.scopusqualityQ4
dc.identifier.startpage513en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4119
dc.identifier.volume28en_US
dc.identifier.wosWOS:000257838900015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmethylationen_US
dc.subjectneoplasmsen_US
dc.subjectepigenesisen_US
dc.subjectgeneticen_US
dc.subjectgene silencingen_US
dc.subjectchromatin assembly and disassemblyen_US
dc.titleMethylation and cancer: Reviewen_US
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Methylation and cancer Review.pdf
Boyut:
288.63 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu