Chemical modification of x-carrageenan with poly (2-hydroxypropylmethacrylamide) through microwave induced graft copolymerization: Characterization and swelling features

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dc.contributor.authorGeyik, Guelcan
dc.contributor.authorIsiklan, Nuran
dc.date.accessioned2025-01-21T16:36:33Z
dc.date.available2025-01-21T16:36:33Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn the last decade, interest in the development of new graft copolymers based on natural polysaccharides has grown remarkably due to their potential applications in the wastewater treatment, biomedical, nanomedicine, and pharmaceutical fields. Herein, a novel graft copolymer of x-carrageenan with poly(2-hydroxypropylmethacrylamide) (x-Crg-g-PHPMA) was synthesized using a 'microwave induced' technique. The synthesized novel graft copolymer has been well characterized in terms of FTIR, 13C NMR, molecular weight determination, TG, DSC, XRD, SEM, and elemental analyses, taking x-carrageenan as a reference. The graft copolymers' swelling characteristics were investigated at pH 1.2 and 7.4. The results of swelling studies displayed that the incorporation of PHPMA groups on x-Crg provides increasing hydrophilicity. The effect of PHPMA percentage in the graft copolymers and pH of the medium on the swelling percentage was studied and the findings exhibited that swelling ability increased with the increment in PHPMA percentage and pH of the me-dium. The best swelling percentage was attained at pH = 7.4 and a grafting percentage of 81 % reaching 1007 % at the end of 240 min. Moreover, cytotoxicity of the synthesized x-Crg-g-PHPMA copolymer was assessed on the L929 fibroblast cell line and obtained to be non-toxic.
dc.description.sponsorshipScientific Research Projects Coordination Unit of K?r?kkale University [2018/057, 2018/055]
dc.description.sponsorshipThe authors are thankful to the Scientific Research Projects Coordination Unit of K?r?kkale University for their financial support (Project number: 2018/057, 2018 and 2018/055, 2018).
dc.identifier.doi10.1016/j.ijbiomac.2023.123888
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid36870636
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.123888
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24331
dc.identifier.volume235
dc.identifier.wosWOS:000972626700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectx-Carrageenan; Graft copolymerization; 2-Hydroxypropylmethacrylamide; Microwave induced copolymerization
dc.titleChemical modification of x-carrageenan with poly (2-hydroxypropylmethacrylamide) through microwave induced graft copolymerization: Characterization and swelling features
dc.typeArticle

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