The effect of levamisole on sheep trachea alone and with trichlorfon combination

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dc.contributor.authorBaydan E.
dc.contributor.authorYildirim E.
dc.contributor.authorInce S.
dc.date.accessioned2020-06-25T15:14:05Z
dc.date.available2020-06-25T15:14:05Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of this study is to determine the effect of levamisole and levamisole-trichlorfon combination on isolated sheep trachea. Contraction was achieved with levamisole concentrations (10-8-10-3 M) on tracheal strips of adult sheep (>1 year of age). Pretreatment with trichlorfon (10-7 M)-levamisole (10-7 M) decreased the pD2 and Emax of Ach when compared to levamisole pretreatment (p?0.01). Pretreatment with levamisole (10-7 M), decreased the Emax (p?0.01) and pD2 (p<0.05) of bethanechol concentrations (10-8-10-3 M) significantly. Pretreatment with atropine (10-6 M) decreased the Emax of levamisole (10-4 M) significantly (p<0.05). To conclude, levamisole acted mainly on the muscarinic receptors of the sheep trachea and this effect was partly inhibited by atropine. Adverse interaction was present between levamisole and trichlorfon. © 2008 Asian Network for Scientific Information.en_US
dc.identifier.doi10.3923/pjbs.2008.1152.1156
dc.identifier.endpage1156en_US
dc.identifier.issn10288880
dc.identifier.issue8en_US
dc.identifier.pmid18819556
dc.identifier.scopus2-s2.0-53749107660
dc.identifier.scopusqualityQ3
dc.identifier.startpage1152en_US
dc.identifier.urihttps://doi.org/10.3923/pjbs.2008.1152.1156
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2018
dc.identifier.volume11en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofPakistan Journal of Biological Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLevamisoleen_US
dc.subjectTracheaen_US
dc.subjectTrichlorfonen_US
dc.titleThe effect of levamisole on sheep trachea alone and with trichlorfon combinationen_US
dc.typeArticle

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