Clinical impact and biomaterial evaluation of autologous platelet gel in cardiac surgery

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dc.contributor.authorGunaydın, Serdar
dc.contributor.authorMcCusker, Kevin
dc.contributor.authorSarıT.
dc.contributor.authorOnur, Mehmet Ali
dc.contributor.authorGürpınar, A.
dc.contributor.authorSevim, Handan
dc.contributor.authorZorlutuna, Y.
dc.date.accessioned2020-06-25T15:14:03Z
dc.date.available2020-06-25T15:14:03Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe compared the clinical efficacy of autologous platelet gel (APG) and gelatine (CONT), including biomaterial evaluation. In a prospective, randomized, controlled trial, 64 patients undergoing complex coronary artery bypass graft (CABG) surgery and/or aortic surgery, in whom the surgeon was able to identify a bleeding site for which conventional means to stop bleeding were impractical or proved unsuccessful, were enrolled. Aortic punch biopsy from each patient was harvested in explant cell (EC) culture media. Hemostasis success for the "oozing" category was 89% in APG and 60% in CONT (p<0.05). For the "heavy bleeding" category, the success rates were 92% in APG and 45% in CONT (p<0.01). Contact of gelatine inhibited EC proliferation and APG increased cell cycling and EC quantity. Phagocytic capacity (PC) was significantly higher in the APG group (p<0.001). APG was significantly better than CONT with respect to hemostatic success rate, effects on wound healing and increased resistance to infection (PC). © 2008 SAGE Publications.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1177/0267659108097783
dc.identifier.endpage186en_US
dc.identifier.issn02676591
dc.identifier.issue3en_US
dc.identifier.pmid19029269
dc.identifier.scopus2-s2.0-60349106660
dc.identifier.scopusqualityQ1
dc.identifier.startpage179en_US
dc.identifier.urihttps://doi.org/10.1177/0267659108097783
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2011
dc.identifier.volume23en_US
dc.identifier.wosWOS:000261114000007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofPerfusion
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExtracorporeal circulationen_US
dc.subjectPlatelet activationen_US
dc.subjectPlatelet gelen_US
dc.subjectPlatelet rich plasmaen_US
dc.subjectSurgical hemostasisen_US
dc.titleClinical impact and biomaterial evaluation of autologous platelet gel in cardiac surgeryen_US
dc.typeArticle

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