Effects of clinoptilolite on heavy metal levels in milk, proinflammatory cytokine responses (IL-1? and IL-6) and oxidative stress in dairy cows

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dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridDURU, OZKAN/0000-0002-8792-442X
dc.authoridALUC, YASAR/0000-0002-2650-2290
dc.contributor.authorKurtdede, Efe
dc.contributor.authorKurtdede, Arif
dc.contributor.authorDuru, Sibel yasa
dc.contributor.authorDuru, Ozkan
dc.contributor.authorKara, Erdal
dc.contributor.authorAluc, Yasar
dc.contributor.authorKaya, Ufuk
dc.date.accessioned2025-01-21T16:38:15Z
dc.date.available2025-01-21T16:38:15Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe effects of clinoptilolite on milk copper (Cu), lead (Pb), zinc (Zn), cadmium (Cd) and iron (Fe) concentrations, proinflammatory cytokine responses, oxidative stress status, whole blood cell counts and liver and kidney functions were investigated in dairy cows exhibiting no signs of any kind of toxicity. Clinoptilolite was added to the feed at a dose of 200 mg kg(-1) body weight in the clinoptilolitetreated group (n = 14), but was not added to the feed in the control group (n = 7). In the milk samples (n = 21) collected before the experiment, the Cu, Pb, Zn, Cd and Fe values were 0.021 +/- 0.020, 0.104 +/- 0.01, 3.42 +/- 0.32, <0.000, 0.56 +/- 0.34 ppm, respectively. At the end of the experiment (30th day), among the elements measured in milk samples collected from the clinoptilolite-treated group, only the Pb value (0.076 +/- 0.01) was lower than the 0-day value of the clinoptilolite-treated group (0.104 +/- 0.01) and the 30th-day value of the control group (0.105 +/- 0.01) was found to be statistically lower. Changes determined at the end of clinoptilolite application in serum superoxide dismutase (SOD), malondialdehyde (MDA), albumin, glucose, urea and urine creatinine/urine total protein (uCr/uTP) values, which were interpreted as the effect of lead exposure before the trial, were evaluated as the positive effect of clinoptilolite. It was concluded that the addition of clinoptilolite to the feed in dairy cows caused a significant decrease in the amount of Pb in milk, and positive changes in the parameters related to oxidative stress in serum and in parameters related to renal function.
dc.identifier.doi10.1556/004.2022.00035
dc.identifier.endpage320
dc.identifier.issn0236-6290
dc.identifier.issn1588-2705
dc.identifier.issue4
dc.identifier.pmid36350569
dc.identifier.scopus2-s2.0-85144587531
dc.identifier.scopusqualityQ2
dc.identifier.startpage313
dc.identifier.urihttps://doi.org/10.1556/004.2022.00035
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24611
dc.identifier.volume70
dc.identifier.wosWOS:000904949300008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAkademiai Kiado Zrt
dc.relation.ispartofActa Veterinaria Hungarica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectclinoptilolite; IL-1 beta; IL-6; milk; MDA; Pb; SOD
dc.titleEffects of clinoptilolite on heavy metal levels in milk, proinflammatory cytokine responses (IL-1? and IL-6) and oxidative stress in dairy cows
dc.typeArticle

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