Corneal and Conjunctival Sensitivity Changes Following Intravitreal Ranibizumab Injection in Diabetic Retinopathy

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dc.contributor.authorOrnek, Nurgul
dc.contributor.authorOrnek, Kemal
dc.contributor.authorErbahceci, Inci Elif
dc.date.accessioned2020-06-25T18:15:44Z
dc.date.available2020-06-25T18:15:44Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionOrnek, Nurgul/0000-0003-3068-1831
dc.description.abstractPurpose: To evaluate corneal and conjunctival sensitivity changes following intravitreal ranibizumab (IVR) injection in eyes with diabetic retinopathy. Methods: Forty-six eyes of 46 patients with diabetic macular edema who underwent intravitreal injection of ranibizumab were included in this prospective study. Fifty eyes of 50 type 2 diabetes mellitus patients served as controls. Each participant underwent a complete ophthalmological examination. Fundus florescein angiography and optical coherence tomography were performed to assess the posterior segment details. IVR (0.5 mg/0.05 mL) was injected from the lower temporal quadrant. Corneal and conjunctival sensitivities were measured using the Cochet-Bonnet esthesiometer. Results: Corneal sensitivity (CS) increased significantly on the first day in temporal and nasal corneas in treated eyes (P=0.005 and P=0.000, respectively). At week one the increase continued and the difference was significant in central, temporal, and nasal corneas (all P=0.000). In fellow eyes, CS increased significantly only in nasal cornea (P=0.004). Only nasal conjunctival sensitivity increased significantly both in treated and fellow eyes at week one (P=0.000 and P=0.005, respectively). Conclusion: IVR may have a potential to increase corneal and conjunctival sensitivities in diabetic retinopathy.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1089/jop.2014.0017
dc.identifier.endpage42en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue1en_US
dc.identifier.pmid25244301
dc.identifier.scopus2-s2.0-84920861578
dc.identifier.scopusqualityQ1
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.1089/jop.2014.0017
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6237
dc.identifier.volume31en_US
dc.identifier.wosWOS:000347391500007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Ocular Pharmacology And Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleCorneal and Conjunctival Sensitivity Changes Following Intravitreal Ranibizumab Injection in Diabetic Retinopathyen_US
dc.typeArticle

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