Effect of whole gut irrigation solutions on gastrointestinal smooth muscle activity

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dc.contributor.authorSoyer, Tutku
dc.contributor.authorAydos, Tolga Reşat
dc.contributor.authorHancerlıoğulları, Oymen
dc.contributor.authorKorkut, Oğuzhan
dc.contributor.authorAktuna, Zuhal
dc.contributor.authorÇakmak, Murat
dc.date.accessioned2020-06-25T17:48:17Z
dc.date.available2020-06-25T17:48:17Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionAydos, Tolga Resat/0000-0002-1832-9336; Soyer, Tutku/0000-0003-1505-6042
dc.description.abstractBackground/Purpose: It has been suggested that whole gut irrigation (WGI), which is a preparation method for large bowel surgery or colonoscopy, increases gastrointestinal motility by creating a gastrocolic reflex. An experimental study was performed to evaluate the effect of different WGI solutions on gastrointestinal smooth muscle activity. Materials and Methods: Thirty Wistar albino rats weighing 200 to 250 g were enrolled in the study. After anesthetization with thiopental sodium (50 mg/kg), proximal ileum, terminal ileum, and colon segments were removed via median laparotomy to obtain a control group. Four different groups (n = 6) were designated as having WGI with saline solution (SS), lactated Ringer's solution (RL), polyethylene glycol (PEG), and dibasic sodium phosphate (DNP). Bowel cleaning was performed by infusing solutions at a rate of 2 mL/min via gastric tube, until the stool was cleared. After completing the bowel cleaning, 2 cm of tissues were removed and suspended in Tyrode solution in an isolated organ bath with a resting tension of I g, to obtain carbachol and potassium chloride (KCl) responses. Results: The mean bowel cleaning times were 87.5 +/- 9.35, 81.6 +/- 9.83, 86.6 +/- 11.6, and 85.0 +/- 0.0 minutes in SS, RL, PEG, and DNP groups, respectively. The total amounts of solutions needed for cleaning were 156.67 +/- 21.6, 195.0 +/- 20.0, 197.5 +/- 32.8, and 70.0 +/- 0.0 mL, respectively. Although there was no difference in cleaning time between the groups, the amount of solution required was significantly less in the DNP group (P = .02). In the proximal ileum segments, though there was no difference in carbachol responses between groups, KCl responses were significantly increased in the RL group (P < .05). When we evaluated the terminal ileum responses, carbachol responses were significantly increased in RL and PEG groups (P = .011) and decreased in the DNP group (P = .049). The KCl responses were also significantly increased in the R-L group with respect to the other groups (P < .05). Colon segments showed no difference in contractile responses with respect to different WGI solutions (P >.05, analysis of variance, post hoc Dunn's test). Conclusion: The different WGI solutions demonstrated no significant differences in colon contractions. The increased contractile responses in the proximal and terminal ileum segments after WGI with RL may be related to the electrolyte composition of RL. Although the lower amount of DNP solution required to achieve bowel cleaning seems to be an advantage, the decreased ileal contractions can be assessed as a disadvantage of DNP irrigations. (c) 2009 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipTurkish Association of Pediatric Surgeonsen_US
dc.description.sponsorshipThis study was recognized with the "Professor Akgun Hicsonmez, Best Scientific Research Project" award by the Turkish Association of Pediatric Surgeons in the 26th National Congress of Pediatric Surgery, June 16-18, 2008, Istanbul, Turkey.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jpedsurg.2009.02.007
dc.identifier.endpage1724en_US
dc.identifier.issn0022-3468
dc.identifier.issue9en_US
dc.identifier.pmid19735814
dc.identifier.scopus2-s2.0-69549118661
dc.identifier.scopusqualityQ1
dc.identifier.startpage1719en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2009.02.007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4391
dc.identifier.volume44en_US
dc.identifier.wosWOS:000270065100014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWhole gut irrigationen_US
dc.subjectGastrointestinalen_US
dc.subjectSmooth muscleen_US
dc.titleEffect of whole gut irrigation solutions on gastrointestinal smooth muscle activityen_US
dc.typeArticle

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