Bioengineering Functional Copolymers. XV. Synthesis and Characterization of Poly(N-isopropyl acrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s and Their PEO Branched Derivatives

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dc.contributor.authorRzayev, Zakir M. O.
dc.contributor.authorTürk, Mustafa
dc.contributor.authorÜzgören, Ayşe
dc.date.accessioned2020-06-25T17:49:12Z
dc.date.available2020-06-25T17:49:12Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionUZGOREN-BARAN, AYSE/0000-0003-1405-2920
dc.description.abstractNovel bioengineering functional terpolymers were synthesized by complex-radical terpolymerization of N-isopropylacrylamide (NIPA), 3,4-dihydro-2H-pyran (DHP) and maleic anhydride (MA) with alpha,alpha'-azoisobisbutyronitrile (AIBN) as a radical initiator in 1,4-dioxane at 65 degrees C under nitrogen atmosphere. Structure compositions and composition-property relationships of terpolymers, and the monomer reactivity ratios were investigated by (1)H ((13)C) NMR spectroscopy, DSC and TGA thermal analysis. The monomer reactivity ratios were determined by modified methods of Jaacks and Kelen-Tudos using (1)H-NMR analysis data: r(1) = 1.14 and r(2) = 0.06 (by (1)H-NMR) and r(1) = 1.07 and r(2) = 0.04 (by N analysis) for NIPA (M(1)) and MA ... DHP (M(2)) monomer-monomer complex pair. An alpha,omega-hydroxy-methoxy-polyethylene oxide branched derivative was synthesized by grafting (esterification) of anhydride units of the terpolymer. Investigation into the factors affecting the antitumor activity revealed that terpolymers containing a combination of H-bonded ionizable amide and carboxylic groups exhibited higher antitumor activity, towards SCLC cancer cells. (c) 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 4285-4295, 2010en_US
dc.description.sponsorshipHU Scientific Research FoundationHacettepe University [HU-BAB-0201602006]; TUBITAK (Turkish National Scientific and Technology Research Council)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG-2386]en_US
dc.description.sponsorshipThis work was carried out in according to the Polymer Science and Engineering of the Chemical Engineering Department, Hacettepe University (HU) relating to the series "Bioengineering Functional Copolymers." The supports of the HU Scientific Research Foundation through the HU-BAB-0201602006 project and the TUBITAK (Turkish National Scientific and Technology Research Council) via TBAG-2386 project are gratefully acknowledged.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/pola.24217
dc.identifier.endpage4295en_US
dc.identifier.issn0887-624X
dc.identifier.issue19en_US
dc.identifier.scopus2-s2.0-77956895997
dc.identifier.scopusqualityN/A
dc.identifier.startpage4285en_US
dc.identifier.urihttps://doi.org/10.1002/pola.24217
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4661
dc.identifier.volume48en_US
dc.identifier.wosWOS:000282304500017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal Of Polymer Science Part A-Polymer Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbioengineeringen_US
dc.subjectcomplex-radical terpolymerizationen_US
dc.subjectfunctionalization of polymersen_US
dc.subjectmonomer reactivity ratiosen_US
dc.subjectstructure-property relationsen_US
dc.subjectsupramolecular structuresen_US
dc.subjectsynthesisen_US
dc.titleBioengineering Functional Copolymers. XV. Synthesis and Characterization of Poly(N-isopropyl acrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s and Their PEO Branched Derivativesen_US
dc.typeArticle

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