Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis

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dc.contributor.authorCil, Aylin Pelin
dc.contributor.authorBang, Heejung
dc.contributor.authorOktay, Kutluk
dc.date.accessioned2020-06-25T18:07:07Z
dc.date.available2020-06-25T18:07:07Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: To estimate age-specific probabilities of live birth with oocyte cryopreservation in nondonor (ND) egg cycles. Design: Individual patient data meta-analysis. Setting: Assisted reproduction centers. Patient(s): Infertile patients undergoing ND mature oocyte cryopreservation. Intervention(s): PubMed was searched for clinical studies on oocyte cryopreservation from January 1996 through July 2011. Randomized and nonrandomized studies that used ND frozen-thawed mature oocytes with pregnancy outcomes were included. Authors of eligible studies were contacted to obtain individual patient data. Main Outcome Measure(s): Live birth probabilities based on age, cryopreservation method, and the number of oocytes thawed, injected, or embryos transferred. Result(s): Original data from 10 studies including 2,265 cycles from 1,805 patients were obtained. Live birth success rates declined with age regardless of the freezing technique. Despite this age-induced compromise, live births continued to occur as late as ages 42 and 44 years with slowly frozen and vitrified oocytes, respectively. Estimated probabilities of live birth for vitrified oocytes were higher than those for slowly frozen. Conclusion(s): The live birth probabilities we calculated would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation. Given the success probabilities, we suggest that policy makers should consider oocyte freezing as an integral part of prevention and treatment of infertility. (C) 2013 by American Society for Reproductive Medicine.en_US
dc.description.sponsorshipNational Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [NIH R01HD053112, R21HD061259]en_US
dc.description.sponsorshipSupported by National Institute of Health grants NIH R01HD053112 and R21HD061259 (to K.O.).en_US
dc.identifier.citationCil, A. P., Bang, H., & Oktay, K. (2013). Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis. Fertility and sterility, 100(2), 492–4999.e3.en_US
dc.identifier.doi10.1016/j.fertnstert.2013.04.023
dc.identifier.endpage+en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue2en_US
dc.identifier.pmid23706339
dc.identifier.scopus2-s2.0-84881170811
dc.identifier.scopusqualityQ1
dc.identifier.startpage492en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2013.04.023
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5482
dc.identifier.volume100en_US
dc.identifier.wosWOS:000322633200039
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOocyte cryopreservationen_US
dc.subjectslow freezingen_US
dc.subjectvitrificationen_US
dc.subjectmeta-analysisen_US
dc.subjectindividual patient dataen_US
dc.titleAge-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysisen_US
dc.typeArticle

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