Cold-induced urticaria in children: A multicenter, retrospective cohort study

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dc.authoridAZKUR, DILEK/0000-0002-4396-9087
dc.authoridKARABAG CITLAK, HILAL/0000-0002-6093-2737
dc.contributor.authorCitlak, Hilal Karabag
dc.contributor.authorAzkur, Dilek
dc.contributor.authorYildiz, Yuksel Kavas
dc.contributor.authorDemirel, Ali Can
dc.contributor.authorKot, Hakan
dc.contributor.authorVezir, Emine
dc.contributor.authorKilic, Mehmet
dc.date.accessioned2025-01-21T16:36:37Z
dc.date.available2025-01-21T16:36:37Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Studies of cold-induced urticaria (ColdU) in pediatric patients are limited and not well characterized. Objective: The objective of the study was to investigate the characteristics of ColdU in children. Methods: A multicenter, retrospective chart review was performed in children ages <= 18 years diagnosed with ColdU at 11 pediatric allergy and immunology centers in Turkey between September 1, 2010, and August 31, 2022. Results: A total of 83 children with ColdU were included, 54.2% were girls, and the mean age of symptom onset was 8.8 years. The median duration of ColdU at the time of diagnosis was significantly higher in the girls than in the boys (1.0 years [0.0-13.8 years] versus 0.3 years [0.0-15.0 years]; p = 0.007). All the patients underwent an ice cube test, and 71.1% were found positive (typical ColdU). The mean +/- standard deviation age of onset was significantly higher in the patients with typical ColdU versus atypical patients (9.4 +/- 4.5 years versus 7.3 +/- 4.5 years; p = 0.041). Swimming alone and in combination with the wind were significantly the most reported triggers in patients with cold-induced anaphylaxis (ColdA) when compared with patients with ColdU and with nonanaphylactic symptoms (70.0% versus 28.9% [p = 0.022], and 50.0% versus 4.1% [p < 0.001], respectively). Only patients with other chronic urticaria were found to be associated with the development of typical ColdU (p = 0.036). The median total serum immunoglobulin E (IgE) was significantly higher in typical ColdU than in atypical patients (72.5 IU/mL [3.86 - 2500 IU/mL] versus 30.0 IU/mL [0.83 - 1215 IU/mL]; p = 0.007); however, total serum IgE differences were not found to affect ColdU resolution between the two groups (p = 0.204). The resolution was documented in 30.4%. Conclusion: Those who were boys and had a positive ice cube test result could have an association with earlier onset of ColdU. Those swimming alone on a windy day were at highest risk for ColdA. It is still unclear what characteristics are associated with the resolution of ColdU, and this warrants further investigation.
dc.identifier.doi10.2500/aap.2023.44.230050
dc.identifier.endpageE43
dc.identifier.issn1088-5412
dc.identifier.issn1539-6304
dc.identifier.issue6
dc.identifier.pmid37919847
dc.identifier.scopus2-s2.0-85176200074
dc.identifier.scopusqualityQ2
dc.identifier.startpageE36
dc.identifier.urihttps://doi.org/10.2500/aap.2023.44.230050
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24353
dc.identifier.volume44
dc.identifier.wosWOS:001107295600009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOcean Side Publications Inc
dc.relation.ispartofAllergy and Asthma Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.titleCold-induced urticaria in children: A multicenter, retrospective cohort study
dc.typeArticle

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