Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis in a rat model

Basit Öğe Kaydı
dc.contributor.authorHanci, Deniz
dc.contributor.authorAltun, Huseyin
dc.contributor.authorCetinkaya, Erdem Atalay
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorCengiz, Betul Peker
dc.contributor.authorCingi, Cemal
dc.date.accessioned2020-06-25T18:16:38Z
dc.date.available2020-06-25T18:16:38Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: The effect of cinnamaldehyde on the treatment of allergic rhinitis (AR) was investigated in rat model. Methods: Twenty-eight female Wistar albino rats were randomly divided into four groups: Group 1 (control) (C), Group 2 (AR with no treatment) (AR + NoTr), Group 3 (AR + Azelastine HCl) (AR + Aze), and Group 4 (AR + cinnamaldehyde) (AR + Cin). At day 21, AR + Aze rats were given an Azelastine HCl drop, and AR + Cin rats were given cinnamaldehyde intranasally. In all groups, allergic symptoms histopathological results were evaluated. Results: The AR + NoTr group showed the worst allergic symptoms, cilia loss and greater inflammation. In the AR + Aze and AR + Cin groups, allergic symptom scores were higher than those in the control group. However, between AR + Aze and AR + CM groups, there were no significant differences in the allergic symptom scores Histopathological analysis revealed vascular congestion and an increase in goblet cell numbers in the AR + Cin group. However, AR + Cin rat nasal mucosa had less plasma cell infiltration compared with the AR + NoTr group. In rats from the AR + Aze group, analysis of the nasal mucosa revealed less eosinophil infiltration than that seen in the AR + NoTr group. A lower score for mast cell (MC) infiltration was observed in the nasal mucosa of rats treated with Azelastine HCl compared with cinnamaldehyde. Conclusions: In this study we observed that both Azelastine HCl and cinnamaldehyde reduced allergic symptoms in an AR rat model. Cinnamaldehyde decreased vascular congestion as well as plasma cell, eosinophil, and inflammatory cell infiltration into the lamina propria. (C) 2016 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Associationen_US
dc.description.sponsorship"With exception of data collection, preparation of this paper including design and planning was supported by Continuous Education and Scientific Research Association." There is no financial support. There is only scientific support.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.ijporl.2016.03.001
dc.identifier.endpage87en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.pmid27063758
dc.identifier.scopus2-s2.0-84960375629
dc.identifier.scopusqualityQ2
dc.identifier.startpage81en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2016.03.001
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6580
dc.identifier.volume84en_US
dc.identifier.wosWOS:000374805000015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergic rhinitis (AR)en_US
dc.subjectCinnamaldehydeen_US
dc.subjectAzelastineen_US
dc.subjectHClen_US
dc.titleCinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis in a rat modelen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Cinnamaldehyde is an effective anti-inflammatory agent for treatment of allergic rhinitis in a rat model.pdf
Boyut:
2.02 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu