Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome

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dc.contributor.authorSoyman, Zeynep
dc.contributor.authorNoyan, Volkan
dc.contributor.authorTulmac, Murat
dc.contributor.authorYucel, Aykan
dc.contributor.authorSagsoz, Nevin
dc.contributor.authorBayrak, Tulin
dc.contributor.authorCakir, Erdinc
dc.date.accessioned2020-06-25T17:51:58Z
dc.date.available2020-06-25T17:51:58Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionYucel, Aykan/0000-0002-5888-692X
dc.description.abstractObjective: To evaluate endothelial function via serum asymmetric dimethylarginine (ADMA) levels, paraoxonase 1 (PON1) activity, and brachial artery flow-mediated dilatation (FMD) in women with polycystic ovary syndrome (PCOS). Design: Prospective case-control study. Setting: University hospital. Patient(s): Thirty patients with PCOS with a mean age of 24.33 +/- 4.50 years and 30 healthy controls matched for body mass index (BMI) and age. Intervention(s): Endothelial function was assessed biochemically with serum ADMA levels and serum PON1 activity and functionally with brachial artery FMD by ultrasonography. Main Outcome Measure(s): Serum ADMA levels, serum PON1 activity, brachial artery FMD, hormonal and biochemical parameters. Result(s): Patients with PCOS had higher levels of free testosterone and insulin, and higher waist-hip ratio and Ferriman Gallwey scores when compared with the controls. Fasting glucose and homeostasis model assessment of insulin resistance were not different between the groups. There was no statistically significant difference in ADMA levels between two groups. Serum PON1 activity and brachial artery FMD were statistically significantly lower in women with PCOS. There was negative correlation between ADMA and PON1 in patients with PCOS. Conclusion(s): Serum PON1 activity and brachial artery FMD, as markers of endothelial dysfunction and cardiovascular risk, were statistically significantly lower in women with PCOS compared with healthy controls matched for age and BMI. Endothelial dysfunction may be seen at earlier ages in patients with PCOS. (Fertil Steril (R) 2011;95:1067-72. (C) 2011 by American Society for Reproductive Medicine.)en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.fertnstert.2010.12.011
dc.identifier.endpage1072en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue3en_US
dc.identifier.pmid21193188
dc.identifier.scopus2-s2.0-79951960682
dc.identifier.scopusqualityQ1
dc.identifier.startpage1067en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2010.12.011
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5046
dc.identifier.volume95en_US
dc.identifier.wosWOS:000287480300040
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric dimethylarginineen_US
dc.subjectbrachial artery flow-mediated dilatationen_US
dc.subjectcardiovascular risken_US
dc.subjectendothelial dysfunctionen_US
dc.subjectparaoxonase 1 activityen_US
dc.subjectpolycystic ovary syndromeen_US
dc.titleSerum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndromeen_US
dc.typeArticle

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