Effects of PON1 QR192 genetic polymorphism and paraoxonase, arylesterase activities on deep vein thrombosis

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dc.authoridMüderrisoğlu, Ahmet/0000-0003-2954-360X
dc.authoridEkim, Meral/0000-0002-7146-5935
dc.authoridCaniklioglu, Aysen/0000-0001-8128-6044
dc.authoridEkim, Hasan/0000-0002-7245-3872
dc.authoridEr, Zafer Cengiz/0000-0001-7129-1157
dc.contributor.authorAkbalik, Hasim
dc.contributor.authorPolat, Muhammet Fevzi
dc.contributor.authorMüderrisoğlu, Ahmet
dc.contributor.authorEr, Zafer Cengiz
dc.contributor.authorCaniklioğlu, Ayşen
dc.contributor.authorEkim, Meral
dc.contributor.authorEkim, Hasan
dc.date.accessioned2025-01-21T16:33:58Z
dc.date.available2025-01-21T16:33:58Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We aimed to evaluate PON1 QR192 polymorphism's (rs662) effects on levels of triglyceride, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein, and paraoxonase-arylesterase activities among deep vein thrombosis patients and healthy subjects. Methods: Forty-five deep vein thrombosis patients and 45 healthy subjects participated in the study. Genetic analysis was performed by using polymerase chain reaction and sequencing. Paraoxonase and arylesterase enzyme activities were determined by a spectrophotometer. Serum levels of triglyceride, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein were measured by a similar method. Results: There were no statistically significant differences between patients and controls regarding the frequency of variant allele for the PON1 QR192 polymorphism, activities of paraoxonase-arylesterase, and level of high-density lipoprotein-cholesterol. Triglyceride, total cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein levels were significantly higher in patients compared to controls (p values were 0.005, 0.0002, 0.009, 0.0009, <0.0001, respectively.) Paraoxonase activity was found to be associated with PON1 QR192 genetic polymorphism (p<0.0001). However, we observed no association of PON1 QR192 polymorphism with arylesterase activity and, levels of triglyceride, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, glucose, and c-reactive protein. Conclusions: There was no statistically significant difference between deep vein thrombosis patients and healthy subjects regarding variant allele frequency for the PON1 QR192 genetic polymorphism. In addition, paraoxonase and arylesterase activities were similar among the groups. These results indicate that PON1 QR192 genetic polymorphism and activity levels of paraoxonase-arylesterase have no effect on the development of deep vein thrombosis.
dc.description.sponsorshipYozgat Bozok University [6601-SBE/19332]
dc.description.sponsorshipThis study was supported by Yozgat Bozok University Research Fund (6601-SBE/19-332). The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
dc.identifier.doi10.1515/tjb-2022-0278
dc.identifier.endpage326
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85168099399
dc.identifier.scopusqualityQ3
dc.identifier.startpage319
dc.identifier.trdizinid1251871
dc.identifier.urihttps://doi.org/10.1515/tjb-2022-0278
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1251871
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23888
dc.identifier.volume48
dc.identifier.wosWOS:000994350100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectarylesterase; deep vein thrombosis; genetic polymorphisms; paraoxonase
dc.titleEffects of PON1 QR192 genetic polymorphism and paraoxonase, arylesterase activities on deep vein thrombosis
dc.typeArticle

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