Vitamin C ameliorates high dose Dexmedetomidine induced liver injury

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dc.contributor.authorArslan, M.
dc.contributor.authorSezen, S. C.
dc.contributor.authorTurgut, H. C.
dc.contributor.authorKocabiyik, M.
dc.contributor.authorArpaci, H.
dc.contributor.authorComu, F. M.
dc.contributor.authorKavutcu, M.
dc.date.accessioned2020-06-25T18:22:30Z
dc.date.available2020-06-25T18:22:30Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractBACKGROUND: We investigated whether vitamin C has protective effects on rat liver tissue treated with different dexmedetomidine doses. MATERIAL AND METHODS: Thirty five wistar albino rats were randomly divided into 5 groups (Control (0.9 % NaCI intraperitoneally (ip), Dexmedetomidine 5 mu g.kg(-1) (ip), Dexmedetomidine 5 mu g.kg(-1) ip plus Vitamin C (100 mng.kg(-1)), Dexmedetomidine 10 mu g.kg(-1) ip and Dexmedetomidine 10 mu g.kg(-1) ip plus Vitamin C (100 mg.kg-1). Histopathological liver injury, superoxide dismutase (SOD) activity and tissue Malondialdehyde levels were investigated. RESULTS: Hepatocyte degeneration was significantly higher in D10 group than those in other study groups (p < 0.0001, p = 0.002, p < 0.0001, p = 0.005, respectively). Similarly, liver tissue sinusoidal dilatation and hepatocyte necrosis were significantly higher in D10 group than those in other groups (p < 0.0001, p < 0.0001, p = 0.002, p < 0.0001 and p < 0.0001, p = 0.046, p < 0.0001 and p = 0.002, respectively). Tissue MDA levels in D10 group were significantly higher than those in control, D5+Vit C and D10+Vit C groups (p = 0.028, p = 0.004, p = 0.031, respectively). SOD enzyme activity in D10 group was significantly lower than in control, D5+Vit C and D10+Vit C groups (p < 0.0001, p = 0.023 and p = 0.031, respectively). CONCLUSION: High dose dexmedetomidine can induce hepatic injury and oxidative stress in rats while pretreatment with vitamin C may be effective in protecting liver tissue against this newly recognized undesirable dexmedetomidine effect (Tab. 2, Fig. 5, Ref. 30). Text in PDF www.elis.sk.en_US
dc.identifier.citationArslan, M., Sezen, S. C., Turgut, H. C., Kocabiyik, M., Arpaci, H., Comu, F. M., Ozturk, L., & Kavutcu, M. (2016). Vitamin C ameliorates high dose Dexmedetomidine induced liver injury. Bratislavske lekarske listy, 117(1), 36–40.en_US
dc.identifier.doi10.4149/BLL_2016_008
dc.identifier.endpage40en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue1en_US
dc.identifier.pmid26810168
dc.identifier.scopus2-s2.0-85014863670
dc.identifier.scopusqualityQ2
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_008
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6768
dc.identifier.volume117en_US
dc.identifier.wosWOS:000370112600008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectvitamin Cen_US
dc.subjectliver histopathologyen_US
dc.subjectMDAen_US
dc.subjectSODen_US
dc.subjectraten_US
dc.titleVitamin C ameliorates high dose Dexmedetomidine induced liver injuryen_US
dc.typeArticle

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