Paper membrane-based SERS platform for the determination of glucose in blood samples

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dc.contributor.authorTorul, Hilal
dc.contributor.authorÇiftçi, Hakan
dc.contributor.authorÇetin, Demet
dc.contributor.authorSuludere, Zekiye
dc.contributor.authorBoyacı, İsmail Hakkı
dc.contributor.authorTamer, Uğur
dc.date.accessioned2020-06-25T18:12:43Z
dc.date.available2020-06-25T18:12:43Z
dc.date.issued2015
dc.departmentKırıkkale Üniversitesi
dc.descriptionSULUDERE, ZEKIYE/0000-0002-1207-5814; Cetin, Demet/0000-0003-1186-4229
dc.description.abstractIn this report, we present a paper membrane-based surface-enhanced Raman scattering (SERS) platform for the determination of blood glucose level using a nitrocellulose membrane as substrate paper, and the microfluidic channel was simply constructed by wax-printing method. The rod-shaped gold nanorod particles were modified with 4-mercaptophenylboronic acid (4-MBA) and 1-decanethiol (1-DT) molecules and used as embedded SERS probe for paper-based microfluidics. The SERS measurement area was simply constructed by dropping gold nanoparticles on nitrocellulose membrane, and the blood sample was dropped on the membrane hydrophilic channel. While the blood cells and proteins were held on nitrocellulose membrane, glucose molecules were moved through the channel toward the SERS measurement area. Scanning electron microscopy (SEM) was used to confirm the effective separation of blood matrix, and total analysis is completed in 5 min. In SERS measurements, the intensity of the band at 1070 cm(-1) which is attributed to B-OH vibration decreased depending on the rise in glucose concentration in the blood sample. The glucose concentration was found to be 5.43 +/- 0.51 mM in the reference blood sample by using a calibration equation, and the certified value for glucose was 6.17 +/- 0.11 mM. The recovery of the glucose in the reference blood sample was about 88 %. According to these results, the developed paper-based microfluidic SERS platform has been found to be suitable for use for the detection of glucose in blood samples without any pretreatment procedure. We believe that paper-based microfluidic systems may provide a wide field of usage for paper-based applications.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [Cost MP 1205-111T983]en_US
dc.description.sponsorshipThe authors acknowledge The Scientific and Technological Research Council of Turkey (TUBITAK) with the project number Cost MP 1205-111T983 for funding.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00216-015-8966-x
dc.identifier.endpage8251en_US
dc.identifier.issn1618-2642
dc.identifier.issn1618-2650
dc.identifier.issue27en_US
dc.identifier.pmid26363778
dc.identifier.scopus2-s2.0-84974620868
dc.identifier.scopusqualityQ1
dc.identifier.startpage8243en_US
dc.identifier.urihttps://doi.org/10.1007/s00216-015-8966-x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6020
dc.identifier.volume407en_US
dc.identifier.wosWOS:000362974100010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofAnalytical And Bioanalytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPaper-based microfluidicsen_US
dc.subjectNitrocellulose membraneen_US
dc.subjectGlucoseen_US
dc.subjectSERSen_US
dc.subjectBlooden_US
dc.titlePaper membrane-based SERS platform for the determination of glucose in blood samplesen_US
dc.typeArticle

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