Dexmedetomidine's Effects on the Livers and Kidneys of Rats with Pancreatic Ischemia-Reperfusion Injury

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridErel, Selin/0000-0002-6040-9815
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.contributor.authorBostanci, Hasan
dc.contributor.authorErel, Selin
dc.contributor.authorKucuk, Ayseguel
dc.contributor.authorKip, Guelay
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorGokgoz, Seda
dc.contributor.authorAtli, Muharrem
dc.date.accessioned2025-01-21T16:37:43Z
dc.date.available2025-01-21T16:37:43Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Pancreatic surgeries inherently cause ischemia-reperfusion (IR) injury, affecting not only the pancreas but also distant organs. This study was conducted to explore the potential use of dexmedetomidine, a sedative with antiapoptotic, anti-inflammatory, and antioxidant properties, in mitigating the impacts of pancreatic IR on kidney and liver tissues. Methods: A total of 24 rats were randomly divided into four groups: control (C), dexmedetomidine (D), ischemia reperfusion (IR), and dexmedetomidine ischemia reperfusion (D-IR). Pancreatic ischemia was induced in the IR and D-IR groups. Dexmedetomidine was administered intraperitoneally to the D and D-IR groups. Liver and kidney tissue samples were subjected to microscopic examinations after hematoxylin and eosin staining. The levels of thiobarbituric acid reactive substances (TBARS), aryllesterase (AES), catalase (CAT), and glutathione S-transferase (GST) enzyme activity were assessed in liver and kidney tissues. The serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine were measured. Results: A comparison of the groups revealed that the IR group exhibited significantly elevated TBARS (p < 0.0001), AES (p = 0.004), and CAT enzyme activity (p < 0.0001) levels in the liver and kidney compared to groups C and D. Group D-IR demonstrated notably reduced histopathological damage (p < 0.05) and low TBARS (p < 0.0001), AES (p = 0.004), and CAT enzyme activity (p < 0.0001) in the liver and kidney as well as low AST and ALT activity levels (p < 0.0001) in the serum compared to the IR group. Conclusion: The preemptive administration of dexmedetomidine before pancreatic IR provides significant protection to kidney and liver tissues, as evidenced by the histopathological and biochemical parameters in this study. The findings underscored the potential therapeutic role of dexmedetomidine in mitigating the multiorgan damage associated with pancreatic surgeries.
dc.identifier.doi10.2147/DDDT.S441773
dc.identifier.endpage1797
dc.identifier.issn1177-8881
dc.identifier.pmid38828020
dc.identifier.scopus2-s2.0-85195007534
dc.identifier.scopusqualityQ1
dc.identifier.startpage1785
dc.identifier.urihttps://doi.org/10.2147/DDDT.S441773
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24507
dc.identifier.volume18
dc.identifier.wosWOS:001236501000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofDrug Design Development and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectpancreas; ischemia-reperfusion; dexmedetomidine; liver; kidney
dc.titleDexmedetomidine's Effects on the Livers and Kidneys of Rats with Pancreatic Ischemia-Reperfusion Injury
dc.typeArticle

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