Antioxidant activities of curcumin in allergic rhinitis

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dc.contributor.authorAltintoprak, Niyazi
dc.contributor.authorKar, Murat
dc.contributor.authorAcar, Mustafa
dc.contributor.authorBerkoz, Mehmet
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorCingi, Cemal
dc.date.accessioned2020-06-25T18:16:07Z
dc.date.available2020-06-25T18:16:07Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe investigated the antioxidant effects of curcumin in an experimental rat model of allergic rhinitis (AR). Female Wistar albino rats (n = 34) were divided randomly into four groups: healthy rats (control group, n = 8), AR with no treatment (AR + NoTr group, n = 10), AR with azelastine HCl treatment (AR + Aze group, n = 8), and AR with curcumin treatment (AR + Curc group, n = 8). On day 28, total blood IgE levels were measured. For measurement of antioxidant activity, the glutathione (GSH) level and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activities were measured in both inferior turbinate tissue and serum. Malondialdehyde (MDA) levels were measured only in inferior turbinate tissue, and paraoxonase (PON) and arylesterase (ARE) activities were measured only in serum. Statistically significant differences were found for all antioxidant measurements (GSH levels and CAT, SOD, GSH-Px activities in the serum and tissue, MDA levels in the tissue, and PON and ARE activities in the serum) between the four groups. In the curcumin group, serum SOD, ARE, and PON and tissue GSH values were higher than the control group. Moreover, tissue GSH levels and serum GSH-Px activities in the curcumin group were higher than in the AR + NoTr group. In the azelastine group, except MDA, antioxidant measurement values were lower than in the other groups. Curcumin may help to increase antioxidant enzymes and decrease oxidative stress in allergic rhinitis. We recommend curcumin to decrease oxidative stress in allergic rhinitis.en_US
dc.description.sponsorshipContinuing Education and Scientific Research Associationen_US
dc.description.sponsorshipWith the exception of data collection, preparation of this paper, including design and planning, was supported by the Continuing Education and Scientific Research Association.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00405-016-4076-4
dc.identifier.endpage3773en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue11en_US
dc.identifier.pmid27146978
dc.identifier.scopus2-s2.0-84965018010
dc.identifier.scopusqualityQ1
dc.identifier.startpage3765en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-016-4076-4
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6424
dc.identifier.volume273en_US
dc.identifier.wosWOS:000385202600037
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectAntioxidanten_US
dc.subjectAllergic rhinitisen_US
dc.subjectRatsen_US
dc.titleAntioxidant activities of curcumin in allergic rhinitisen_US
dc.typeArticle

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