Routine computed tomography screening of the chest in high-risk cardiac transplant recipients may improve survival

Basit Öğe Kaydı
dc.contributor.authorRosenbaum, D.H.
dc.contributor.authorBhojani, R.A.
dc.contributor.authorDikmen, E.
dc.contributor.authorKaiser, P. A.
dc.contributor.authorPaul, M.C.
dc.contributor.authorWait, M.A.
dc.date.accessioned2020-06-25T17:40:17Z
dc.date.available2020-06-25T17:40:17Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description25th Annual Meeting of the International-Society-of-Heart-and-Lung-Transplantation -- APR 06-09, 2005 -- Philadelphia, PA
dc.description.abstractBackground: Multiple studies have demonstrated an increased incidence of lung cancer in the heart transplant population. We reviewed our cardiac transplantation experience with respect to the development of bronchogenic carcinoma and explored the role of routine chest computed tomography (CT) in its surveillance. Methods: We performed a review of our cardiac transplantation experience, highlighting the incidence of lung cancer, and we analyzed our recent experience with screening chest CT in lung cancer surveillance in this patient group. Results: Eighteen patients developed 20 cases of bronchogenic carcinoma for an incidence of 6.83%. In 10 cases, the patients underwent surgical resection; however, in the remaining cases, the patients were either treated with chemotherapy and/or radiation or they died before initiation of therapy. The actuarial 1-, 2- and 5-year overall survival rates were 49%, 29% and 13%, respectively. The median survival of patients who underwent surgical resection was 28 months (3 to 85 months), whereas the median survival of patients who were either ineligible for surgery or died before initiation of treatment was only 1 month (1 to 13 months). All patients diagnosed with lung cancer by chest CT underwent surgical resection; however, only 37.5% of patients diagnosed with lung cancer by chest X-ray were found at,in appropriate stage for resection (p = 0.025). Conclusions: Cardiac transplant recipients have a significant risk of developing bronchogenic carcinoma. Routine chest CT screening in high-risk patients may enable clinicians to identify disease earlier, which is essential for the option of surgical resection and, therefore, prolonged survival.en_US
dc.description.sponsorshipInt Soc Heart & Lung Transplantaten_US
dc.description.sponsorshipNIGMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [5T32GM08593]en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.healun.2005.06.020
dc.identifier.endpage2047en_US
dc.identifier.issn1053-2498
dc.identifier.issn1557-3117
dc.identifier.issue12en_US
dc.identifier.pmid16364847
dc.identifier.scopus2-s2.0-29144443021
dc.identifier.scopusqualityQ1
dc.identifier.startpage2043en_US
dc.identifier.urihttps://doi.org/10.1016/j.healun.2005.06.020
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3379
dc.identifier.volume24en_US
dc.identifier.wosWOS:000234308700006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Heart And Lung Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleRoutine computed tomography screening of the chest in high-risk cardiac transplant recipients may improve survivalen_US
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Bildiri ve Sunum Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu