Apoptosis in testicular tissue of rats after vasectomy: Evaluation of eNOS, iNOS immunoreactivities and the effects of ozone therapy

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dc.contributor.authorAlpcan S.
dc.contributor.authorBaşar H.
dc.contributor.authorAydos T.R.
dc.contributor.authorKul O.
dc.contributor.authorKısa Ü.
dc.contributor.authorBaşar M.M.
dc.date.accessioned2020-06-25T15:17:28Z
dc.date.available2020-06-25T15:17:28Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: We aimed to investigate the changes in endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) expression and apoptotic index in rat testicular tissue, as well as serum and seminal plasma sex hormone levels after vasectomy, and the effect of ozone therapy (OT).Material and methods: Adult male Wistar rats were used (n=6 per group). Control (G1), sham for 4 weeks (G2) or 6 weeks (G3), orchiectomy at the 4th (G4) or 6th (G5) week after left vasectomy, orchiectomy at the 4th (G6) or 6th (G7) week after bilateral vasectomy, orchiectomy after 6 weeks OT following left (G8) or bilateral (G9) vasectomy, orchiectomy after 6 weeks OT (G10).Results: In the left testes, while there were increases in eNOS and iNOS immunoreactivity and apoptotic indexes in G4 and G5, no changes were observed in contralateral testis. These values increased in G6 and G7, while OT inhibited these parameters in the left testis of G8 and both testes of G9. Sex hormone levels did not show any changes after vasectomy and ozone therapy.Conclusion: While OT was found to be protective against some parameters mentioned above under stress conditions, it seemed to cause some harmful effects when used in healthy conditions. © 2014 by Turkish Association of Urology.en_US
dc.identifier.doi10.5152/tud.2014.76892
dc.identifier.endpage206en_US
dc.identifier.issn13005804
dc.identifier.issue4en_US
dc.identifier.pmid26328178
dc.identifier.scopus2-s2.0-84916596734
dc.identifier.scopusqualityN/A
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.5152/tud.2014.76892
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2387
dc.identifier.volume40en_US
dc.identifier.wosWOS:000420589000002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAVES Ibrahim Karaen_US
dc.relation.ispartofTurk Uroloji Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectENOSen_US
dc.subjectINOSen_US
dc.subjectOzone therapyen_US
dc.subjectVasectomyen_US
dc.titleApoptosis in testicular tissue of rats after vasectomy: Evaluation of eNOS, iNOS immunoreactivities and the effects of ozone therapyen_US
dc.typeArticle

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