Prognostic significance of micropapillary pattern in lung adenocarcinoma and expression of apoptosis-related markers: caspase-3, bcl-2, and p53

Basit Öğe Kaydı
dc.contributor.authorCakir, Ebru
dc.contributor.authorYilmaz, Aydin
dc.contributor.authorDemirag, Funda
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorSahin, Sezgi
dc.contributor.authorYazici, Ulku Eren
dc.contributor.authorAydin, Mehtap
dc.date.accessioned2020-06-25T17:51:42Z
dc.date.available2020-06-25T17:51:42Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.descriptionDemirag, Funda/0000-0003-4790-8369
dc.description.abstractCakir E, Yilmaz A, Demirag F, Oguztuzun S, Sahin S, Yazici UE, Aydin M. Prognostic significance of micropapillary pattern in lung adenocarcinoma and expression of apoptosis-related markers: caspase-3, bcl-2, and p53. APMIS 2011; 119: 574-80. We evaluated the clinicopathological characteristics and prognostic significance of lung adenocarcinoma with micropapillary pattern (MPP) and analyzed the expression of apoptosis-related markers: caspase-3, bcl-2, and p53. A series of 166 lung adenocarcinoma that had been surgically resected between 2004 and 2009 were reviewed. Histopathologic patterns, presence of tumor necrosis, mitosis, lymphovascular and perineural invasion, the status of pleura, and tumor differentiation were examined. Of the 166 patients; 71 were stage I, 35 stage II, 51 stage III, and nine stage IV. Histologically they were divided into two groups: MPP-positive (n = 55) and MPP-negative (n = 111). The following items were significantly more frequent in the MPP positive group: female gender (p = 0.03), lymph node metastasis (p = 0.031), and pleural invasion (p = 0.045). Age, smoking status, tumor stage, lymphatic invasion, perineural invasion, mitotic count, and survival rates had no statistically significant difference between groups (p > 0.05). In MPP positive tumors, visceral pleural invasion was identified significantly more frequent than in MPP negative tumors, at stage I. Tumors with MPP showed elevated expressions of caspase-3 (94.5%), p53 (60%), and bcl-2 (54.5%). In MPP positive group, the expression of these three markers had no statistically significant impact on survival. In whole population, bcl-2 expression was correlated with a better outcome. We conclude that MPP is associated with poor prognostic factors both in early and late stages in lung adenocarcinoma. Bcl-2 provides prognostic information independent from the MPP.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1111/j.1600-0463.2011.02778.x
dc.identifier.endpage580en_US
dc.identifier.issn0903-4641
dc.identifier.issue9en_US
dc.identifier.pmid21851414
dc.identifier.scopus2-s2.0-80051903574
dc.identifier.scopusqualityQ1
dc.identifier.startpage574en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-0463.2011.02778.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4960
dc.identifier.volume119en_US
dc.identifier.wosWOS:000294073500002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofApmis
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLung adenocarcinomaen_US
dc.subjectmicropapillary patternen_US
dc.subjectcaspase-3en_US
dc.subjectbcl-2en_US
dc.subjectp53en_US
dc.titlePrognostic significance of micropapillary pattern in lung adenocarcinoma and expression of apoptosis-related markers: caspase-3, bcl-2, and p53en_US
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Prognostic significance of micropapillary pattern in lung adenocarcinoma and expression of apoptosis-related markers caspase-3, bcl-2, and p53.pdf
Boyut:
372 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Diğer Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu