Bi-layered constructs of poly(glycerol-sebacate)-beta-tricalcium phosphate for bone-soft tissue interface applications

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dc.contributor.authorTevlek, Atakan
dc.contributor.authorHosseinian, Pezhman
dc.contributor.authorOgutcu, Cansel
dc.contributor.authorTurk, Mustafa
dc.contributor.authorAydin, Halil Murat
dc.date.accessioned2020-06-25T18:23:10Z
dc.date.available2020-06-25T18:23:10Z
dc.date.issued2017
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study aims to establish a facile protocol for the preparation of a bi-layered poly(glycerol-sebacate) (PGS)/beta-tricalcium phosphate (beta-TCP) construct and to investigate its potential for bone-soft tissue engineering applications. The layered structure was prepared by distributing the ceramic particles within a prepolymer synthesized in a microwave reactor followed by a cross-linking of the final construct in vacuum (<10 mbar). The vacuum stage led to the separation of cross-linked elastomer (top) and ceramic (bottom) phases. Results showed that addition of beta-TCP particles to the elastomer matrix after the polymerization led to an increase in compression strength (up to 14 +/- 2.3 MPa). Tensile strength (sigma), Young's modulus (E), and elongation at break (%) values were calculated as 0.29 +/- 0.03 MPa and 0.21 +/- 0.03; 038 +/- 0.02 and 1.95 +/- 0.4; and 240 +/- 50% and 24 +/- 2% for PGS and PGS/beta-TCP bi-layered constructs, respectively. Morphology was characterized by using Scanning Electron Microscopy (SEM) and micro-computed tomography (mu-CT). Tomography data revealed an open porosity of 35% for the construct, mostly contributed from the ceramic phase since the elastomer side has no pore. Homogeneous beta-TCP distribution within the elastomeric structure was observed. Cell culture studies confirmed biocompatibility with poor elastomer-side and good bone-side cell attachment. In a further study to investigate the osteogenic properties, the construct were loaded with BMP-2 and/or TGF-beta 1. The PGS/beta-TCP bi-layered constructs with improved mechanical and biological properties have the potential to be used in bone-soft tissue interface applications where soft tissue penetration is a problem. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) under the COST Action [213M184, MP1301]en_US
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 213M184) under the COST Action MP1301. The authors would also like to thank BMT Calsis Co. for providing beta-tricalcium phosphate particles.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.msec.2016.11.082
dc.identifier.endpage324en_US
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid28024592
dc.identifier.scopus2-s2.0-84998996848
dc.identifier.scopusqualityN/A
dc.identifier.startpage316en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2016.11.082
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7030
dc.identifier.volume72en_US
dc.identifier.wosWOS:000392165600038
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPoly(glycerol-sebacate)en_US
dc.subjectbeta-tricalcium phosphateen_US
dc.subjectBi-layereden_US
dc.subjectGuided bone regeneration (GBR)en_US
dc.subjectTissue engineeringen_US
dc.titleBi-layered constructs of poly(glycerol-sebacate)-beta-tricalcium phosphate for bone-soft tissue interface applicationsen_US
dc.typeArticle

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