The relationship between vascular endothelial growth factor (VEGF) and microalbuminuria in patients with essential hypertension

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dc.contributor.authorEbinç, Fatma Ayerden
dc.contributor.authorHaksun, Ebinc
dc.contributor.authorUlver, Derici Boztepe
dc.contributor.authorKoc, Eyuep
dc.contributor.authorErten, Yasemin
dc.contributor.authorAltok, Kadriye Reis
dc.contributor.authorSindel, Şükrü
dc.date.accessioned2020-06-25T17:48:03Z
dc.date.available2020-06-25T17:48:03Z
dc.date.issued2008
dc.description.abstractObjective The existence of microalbuminuria (MAU) in patients with essential hypertension is a strong indicator of microvascular damage. Although endothelial dysfunction and increased vascular permeability both have a role in the development of MAU, its ethiopathogenesis in hypertensive patients is not yet clearly understood. Vascular endothelial growth factor (VEGF) is the most important regulator of pathological or physiological angiogenesis and it additionally leads to increased vascular permeability. This study aims to assess the relationship of serum VEGF levels to MAU in non-complicated, newly-diagnosed essential hypertensive patients (EHs). Methods This study included 30 newly-diagnosed EHs with MAU, 46 newly-diagnosed EHs without MAU and 46 healthy controls. None of the EHs had diabetes, renal impairment or atherosclerotic diseases. Serum VEGF levels were measured using the ELISA method. Results Serum levels of VEGF were significantly higher in EHs with MAU when compared with patients without MAU (225.15+/-109.34 pg/mL versus 166.78+/-114.35 pg/mL, p: 0.04) or controls (225.15+/-109.34 pg/mL versus 144.91+/-96.60 pg/mL, p: 0.007). On the other hand, no significant difference was observed between the non-MAU and control groups. In the univariate analysis, serum levels of VEGF, were positively correlated with systolic blood pressure (R: 0.253 p: 0.001), diastolic blood pressure (R: 0.162 p: 0.04), mean arterial pressure (R: 0.239 p: 0.002), creatinine clearance (R: 0.172 p: 0.04) and MAU (R: 0.338 p: 0.002). In the multiple linear regression analysis, VEGF levels were independently related to MAU (beta: 0.248, p: 0.02). Conclusion VEGF levels are higher in EHs in the presence of MAU. These high values may be important in the early diagnosis of vascular damage in EHs. Additionally, VEGF may increase glomerular permeability and lead to MAU in EHs.en_US
dc.identifier.citationAyerden Ebinç, F., Haksun, E., Ulver, D. B., Koç, E., Erten, Y., Reis Altok, K., Bali, M., Turgay, A., & Sindel, S. (2008). The relationship between vascular endothelial growth factor (VEGF) and microalbuminuria in patients with essential hypertension. Internal medicine (Tokyo, Japan), 47(17), 1511–1516.en_US
dc.identifier.doi10.2169/internalmedicine.47.1122
dc.identifier.endpage1516en_US
dc.identifier.issn0918-2918
dc.identifier.issn1349-7235
dc.identifier.issue17en_US
dc.identifier.pmid18758126
dc.identifier.scopus2-s2.0-56349135334
dc.identifier.scopusqualityQ3
dc.identifier.startpage1511en_US
dc.identifier.urihttps://doi.org10.2169/internalmedicine.47.1122
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4265
dc.identifier.volume47en_US
dc.identifier.wosWOS:000259221300003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJapan Soc Internal Medicineen_US
dc.relation.ispartofInternal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthypertensionen_US
dc.subjectmicroalbuminuriaen_US
dc.subjectVEGFen_US
dc.titleThe relationship between vascular endothelial growth factor (VEGF) and microalbuminuria in patients with essential hypertensionen_US
dc.typeArticle

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