Synthesis and biological evaluation of novel urea, thiourea and squaramide diastereomers possessing sugar backbone

Basit Öğe Kaydı
dc.contributor.authorIsilar, Ozer
dc.contributor.authorBulut, Adnan
dc.contributor.authorYaglioglu, Ayse Sahin
dc.contributor.authorDemirtas, Ibrahim
dc.contributor.authorArat, Esra
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2021-01-14T18:10:36Z
dc.date.available2021-01-14T18:10:36Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionBulut, Adnan/0000-0001-9322-0325
dc.description.abstractA series of novel chiral 14 urea, thiourea and squaramide stereoisomers possessing carbohydrate backbones as well as amide functional groups was synthesized and characterized by their, H-1 NMR, C-13 NMR, FT-IR, HRMS, optical rotation, and melting points. Their antiproliferative activities were investigated against HeLa and PC3 cell lines. The compounds 9, 11 and 12 showed better activities at 25 mu M against PC3 cell line with respect to the standard 5-fluorouracil (5-FU). Especially, the compounds 9 and 11 showed higher activities than the standard 5-FU even at low concentration (5 mu M) against HeLa cell line. IC50 results also confirm these activities. The compounds 9, 10 and 11 have the IC50 values of 1.10 mu M, 1.51 mu M and 1.02 mu M, respectively while 5-FU has 2.51 mu M. Moreover, their cytotoxicity tests have proven that their viabilities were in between 50% and 100%.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Kirikkale UniversityKirikkale University [2017/060]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Kirikkale University. Project number: 2017/060.en_US
dc.identifier.citationBu makale açık erişimli değildir.en_US
dc.identifier.doi10.1016/j.carres.2020.107991
dc.identifier.issn0008-6215
dc.identifier.issn1873-426X
dc.identifier.pmid32259705
dc.identifier.scopus2-s2.0-85082688581
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.carres.2020.107991
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12690
dc.identifier.volume492en_US
dc.identifier.wosWOS:000537685900004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofCARBOHYDRATE RESEARCH
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSugaren_US
dc.subjectUreaen_US
dc.subjectThioureaen_US
dc.subjectSquaramideen_US
dc.subjectAntiproliferative activityen_US
dc.subjectCytotoxicityen_US
dc.titleSynthesis and biological evaluation of novel urea, thiourea and squaramide diastereomers possessing sugar backboneen_US
dc.typeArticle

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