The Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapy

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dc.contributor.authorNasseri, Behzad
dc.contributor.authorTurk, Mustafa
dc.contributor.authorKosemehmetoglu, Kemal
dc.contributor.authorKaya, Murat
dc.contributor.authorPiskin, Erhan
dc.contributor.authorRabiee, Navid
dc.contributor.authorWebster, Thomas J.
dc.date.accessioned2021-01-14T18:11:06Z
dc.date.available2021-01-14T18:11:06Z
dc.date.issued2020
dc.departmentKKÜ
dc.descriptionRabiee, Navid/0000-0002-6945-8541; Kosemehmetoglu, Kemal/0000-0002-7747-0460; Kaya, Murat/0000-0002-2458-8924
dc.description.abstractBackground: The development of highly efficient nanoparticles to convert light to heat for anti-cancer applications is quite a challenging field of research. Methods: In this study, we synthesized unique pimpled gold nanospheres (PGNSs) for plasmonic photothermal therapy (PPTT). The light-to-heat conversion capability of PGNSs and PPTT damage at the cellular level were investigated using a tissue phantom model. The ability of PGNSs to induce robust cellular damage was studied during cytotoxicity tests on colorectal adenocarcinoma (DLD-1) and fibroblast cell lines. Further, a numerical model of plasmonic (COMSOL Multiphysics) properties was used with the PPTT experimental assays. Results: A low cytotoxic effect of thiolated polyethylene glycol (SH-PEG400-SH-) was observed which improved the biocompatibility of PGNSs to maintain 89.4% cell viability during cytometry assays (in terms of fibroblast cells for 24 hrs at a concentration of 300 mu g/mL). The heat generated from the nanoparticle-mediated phantom models resulted in Delta T=30 degrees C, Delta T=23.1 degrees C and Delta T=21 degrees C for the PGNSs, AuNRs, and AuNPs, respectively (at a 300 mu g/mL concentration and for 325 sec). For the in vitro assays of PPTT on cancer cells, the PGNS group induced a 68.78% lethality (apoptosis) on DLD-1 cells. Fluorescence microscopy results showed the destruction of cell membranes and nuclei for the PPTT group. Experiments further revealed a penetration depth of sufficient PPTT damage in a physical tumor model after hematoxylin and eosin (H&E) staining through pathological studies (at depths of 2, 3 and 4 cm). Severe structural damages were observed in the tissue model through an 808-nm laser exposed to the PGNSs. Conclusion: Collectively, such results show much promise for the use of the present PGNSs and photothermal therapy for numerous anti-cancer applications.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under the 1003 classification project.en_US
dc.identifier.citationNasseri, B., Türk, M., Kosemehmetoglu, K., Kaya, M., Piskin, E., Rabiee, N., Webster, TJ. The Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapy. Int J Nanomedicine,15:2903-2920.en_US
dc.identifier.doi10.2147/IJN.S248327
dc.identifier.endpage2920en_US
dc.identifier.issn1178-2013
dc.identifier.pmid32425523
dc.identifier.scopus2-s2.0-85083977009
dc.identifier.scopusqualityQ1
dc.identifier.startpage2903en_US
dc.identifier.urihttps://doi.org/10.2147/IJN.S248327
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12879
dc.identifier.volume15en_US
dc.identifier.wosWOS:000527880400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDOVE MEDICAL PRESS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF NANOMEDICINE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectplasmonicen_US
dc.subjectphotothermal therapyen_US
dc.subjectgold nanoparticlesen_US
dc.subjectcolorectal cellsen_US
dc.subjectpathologyen_US
dc.titleThe Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapyen_US
dc.typeArticle

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