Effects of Lamotrigine and Topiramate on Brain Maturation and Cognitive Functions in Offspring of Pregnant Rats - Preliminary Study

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dc.contributor.authorDag, Ersel
dc.contributor.authorDag, Zeynep O.
dc.contributor.authorBaydas, Giyasettin
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorYoldas, Tahir K.
dc.contributor.authorMungen, Bulent
dc.contributor.authorBal, Ramazan
dc.date.accessioned2020-06-25T18:12:07Z
dc.date.available2020-06-25T18:12:07Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.descriptionTUZCU, MEHMET/0000-0002-1329-3143; Bal, Ramazan/0000-0003-3829-8669; Baydas, Giyasettin/0000-0002-9206-3177
dc.description.abstractBackground. Antiepileptic drugs (AED) which are used to treat seizures in pregnant women, infants, and young children may cause cognitive impairment or other uncertain injury. However, the precise mechanisms responsible for the negative effects of new AEDs like lamotrigine (LTG) and topiramate (TPM) in the developing brain are still unclear. Objectives. To investigate the GFAP, NCAM and S100B levels in the whole brain of newborn rats on postnatal 1 day and in the hippocampus of adult rats to find out the effect of TPM and LTG on cognitive impairment and brain maturation. Material and Methods. Twenty eight pregnant rats were randomly divided into 7 groups with 4 animals in each group. The first group, receiving no drugs, was assigned as the control group. The study groups received intraperitoneal TPM or LTG injections in each trimester. Western blot analysis of the GFAP, NCAM and S100B was performed in the offspring. Behavioral tests were performed at postnatal day 75. Results. The rats in the TPM-I and TPM-III groups had a significant impairment in escape latency on the 5th day as compared to the control rats in a Morris water maze test. In addition, in the expression of astrocyte derived markers, GFAP was upregulated, whereas S100 beta and NCAM were downregulated in the whole brain on postnatal day 1, in offspring exposed to LTG and TPM in utero. Conclusions. The detrimental effects of TPM and LTG appear to be confined particularly to the early stages of brain development. And TPM seems to have a partial role in the cognitive impairmenten_US
dc.identifier.citationDag, E., Dag, Z. O., Baydas, G., Tuzcu, M., Yoldas, T. K., Mungen, B., & Bal, R. (2014). Effects of lamotrigine and topiramate on brain maturation and cognitive functions in offspring of pregnant rats - preliminary study. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 23(5), 691–698.en_US
dc.identifier.doi10.17219/acem/37219
dc.identifier.endpage698en_US
dc.identifier.issn1899-5276
dc.identifier.issue5en_US
dc.identifier.pmid25491681
dc.identifier.scopus2-s2.0-84931387682
dc.identifier.scopusqualityQ1
dc.identifier.startpage691en_US
dc.identifier.urihttps://doi.org/10.17219/acem/37219
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5743
dc.identifier.volume23en_US
dc.identifier.wosWOS:000346149200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances In Clinical And Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttopiramateen_US
dc.subjectlamotrigineen_US
dc.subjectbrain developmenten_US
dc.subjectcognitive functionsen_US
dc.titleEffects of Lamotrigine and Topiramate on Brain Maturation and Cognitive Functions in Offspring of Pregnant Rats - Preliminary Studyen_US
dc.typeArticle

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