Evaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injection

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dc.contributor.authorOğurel, Tevfik
dc.contributor.authorOğurel, Reyhan
dc.contributor.authorÖzkal, Fatma
dc.contributor.authorÖlmez, Yasar
dc.contributor.authorÖrnek, Nurgül
dc.contributor.authorOnaran, Zafer
dc.date.accessioned2020-06-25T18:34:00Z
dc.date.available2020-06-25T18:34:00Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description0000-0003-0658-2286
dc.description.abstractPurpose: To evaluate the analgesic effect of topical 0.1% nepafenac solution during intravitreal Ozurdex injection. Methods: This prospective, randomized, double-blind placebo-controlled study included 59 patients who were diagnosed with retinal vein occlusion or pseudophakic cystoid macular edema and were selected to receive intravitreal Ozurdex injection. The patients were divided into two groups. Group 1, consisting of 31 eyes of 31 patients, received topical 0.1% nepafenac with topical anesthesia (0.5% proparacaine HCl, Alcaine; Alcon, TX, USA), and group 2, consisting of 28 eyes of 28 patients, received placebo with topical anesthesia. Results: There were 14 (45.2%) men and 17 (54.8%) women in group 1 and 16 (57.1%) men and 12 (42.9%) women in group 2. The mean age of the subjects was 64.42 +/- 5.51 years in group 1 and 62.32 +/- 7.54 years in group 2. The median visual analog scale pain score was 2 (1-3) in group 1 and 4 (1-6) in group 2. The visual analog scale pain score was significantly lower in group 1 than in group 2 (p < 0.001). Conclusion: Topical 0.1% nepafenac has an additive analgesic effect when combined with topical anesthesia for intravitreal Ozurdex injection.en_US
dc.identifier.doi10.1177/2515841419861856
dc.identifier.issn2515-8414
dc.identifier.pmid31317125
dc.identifier.scopus2-s2.0-85108115581
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1177/2515841419861856
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7743
dc.identifier.volume11en_US
dc.identifier.wosWOS:000478596400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTherapeutic Advances In Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectintravitreal injectionen_US
dc.subjectnepafenacen_US
dc.subjectOzurdexen_US
dc.subjectpainen_US
dc.titleEvaluation effectiveness of 0.1% nepafenac on injection-related pain in patients undergoing intravitreal Ozurdex injectionen_US
dc.typeArticle

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