Effect of methylphenidate at different doses on new bone formation with rapid maxillary expansion: A micro-CT and histomorphometric study in rats

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dc.authoridOnder, M Ercument/0000-0002-1488-616X
dc.contributor.authorDursun, S.
dc.contributor.authorErhamza, T. Sezen
dc.contributor.authorOnder, M. E.
dc.contributor.authorDuzcu, S. Erdogan
dc.date.accessioned2025-01-21T16:37:57Z
dc.date.available2025-01-21T16:37:57Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives This study aimed to evaluate the effect of systemically administered methylphenidate hydrochloride (MPH) on new bone formation in premaxillary suture after rapid maxillary expansion (RME). Setting and Sample Population Thirty-three Wistar rats were divided into four groups: Group 1 (high dose, 30/60 mg/kg MPH), Group 2 (low dose, 4/10 mg/kg MPH), Group 3 (positive control) and Group 4 (negative control). Methods RME was applied on the 70th day of the study. A 5-day RME period was followed by a 12-day retention period. The experiment was terminated on the 87th day. Micro-CT for radiological evaluation, haematoxylin-eosin and Masson's trichrome staining methods were used for histomorphometric evaluation. Results Among experimental groups with RME, the lowest number of osteoblasts and capillaries in Group 1 (P < .05). New bone formation, fibrous callus formation, distal osteotomy line, proximal osteotomy union and cortex remodelling were observed to be lower in Group 1 and Group 2 than Group 3 (P < .05). There was a statistically significant difference between Group 4 and each of the other groups (P = .000) in the evaluation of the results for bone mineral density, bone volume, bone volume percentage, trabecular thickness and trabecular number. Conclusions MPH reduces cellular activity for new bone formation in suture in RME groups. Before performing rapid maxillary expansion in patients using MPH, the use of the drug should be postponed after a multidisciplinary decision process or clinical doses should be lowered.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [118S720]
dc.description.sponsorshipThis research was supported by The Scientific and Technological Research Council of Turkey (TUBITAK)-Project no: 118S720.
dc.identifier.doi10.1111/ocr.12547
dc.identifier.endpage392
dc.identifier.issn1601-6335
dc.identifier.issn1601-6343
dc.identifier.issue3
dc.identifier.pmid34821040
dc.identifier.scopus2-s2.0-85120087146
dc.identifier.scopusqualityQ1
dc.identifier.startpage384
dc.identifier.urihttps://doi.org/10.1111/ocr.12547
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24576
dc.identifier.volume25
dc.identifier.wosWOS:000723365500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofOrthodontics & Craniofacial Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectmethylphenidate; new bone formation; rapid maxillary expansion; rat
dc.titleEffect of methylphenidate at different doses on new bone formation with rapid maxillary expansion: A micro-CT and histomorphometric study in rats
dc.typeArticle

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