An evaluation of the efficacy of indomethacin in experimentally induced acute sinusitis in rats

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dc.authoridMuluk, Nuray Bayar/0000-0003-3602-9289
dc.contributor.authorKurt, Y.
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorYildirim, C.
dc.contributor.authorDönmez, D. Burukoğlu
dc.contributor.authorErol, K.
dc.contributor.authorCingi, C.
dc.date.accessioned2025-01-21T16:35:36Z
dc.date.available2025-01-21T16:35:36Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: We evaluated how efficacious indomethacin, at two different doses, is in the treatment of an experimental model of sinusitis in rats. MATERIALS AND METHODS: Twenty-one Wistar albino rats (all male) were sorted at random into one of three groups: 1(st) group (n=7) was placebo. 2(nd) group (n=7). These rats had sinusitis induced experimentally, following indomethacin 3 mg/kg, 5 days was administered to them. 3(rd) group (n=7). These rats had sinusitis induced experimentally, following indomethacin 6 mg/kg, 5 days was administered to them. The animals' sinonasal mucosae were examined histopathologically by standard light microscopy. RESULTS: Experimental sinusitis was observed in the 2(nd) and 3(rd) groups, but not in the rats administered a placebo. Although the in-flammatory features of sinusitis were found to be significantly decreased in the animals administered indomethacin 3 mg/kg (the 2(nd) group), this anti-inflammatory effect was even greater in the 3(rd) group, where indomethacin 6 mg/kg had been administered. Indomethacin at either dose was superior to placebo in reducing inflammatory features of sinusitis. CONCLUSIONS: Topical use of indomethacin nasal drops decreased the inflammatory features in experimentally induced acute sinusitis. Moreover, a higher dose of indomethacin (6 mg/kg) was more efficacious than a lower dose (3 mg/kg). The present study is valuable as an initial step in showing the need to undertake human trials to see the effect of indomethacin nasal drops on sinusitis in humans. In acute rhinosinusitis, the use of topical anti-inflammatory drops may help to decrease the symptoms and may be used adjunctively with antibiotic treatment.
dc.identifier.endpage6128
dc.identifier.issn1128-3602
dc.identifier.issue17
dc.identifier.pmid36111914
dc.identifier.scopus2-s2.0-85138266134
dc.identifier.scopusqualityQ2
dc.identifier.startpage6121
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24165
dc.identifier.volume26
dc.identifier.wosWOS:000860601000016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectExperimental sinusitis; Rats; Indomethacin drops; Topical use
dc.titleAn evaluation of the efficacy of indomethacin in experimentally induced acute sinusitis in rats
dc.typeArticle

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