Preparation, characterization, and evaluation of antibacterial and cytotoxic activity of chitosan-polyethylene glycol nanoparticles loaded with amoxicillin as a novel drug delivery system

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dc.contributor.authorGuncum, Enes
dc.contributor.authorIsiklan, Nuran
dc.contributor.authorAnlas, Ceren
dc.contributor.authorBulut, Elif
dc.contributor.authorBakirel, Tulay
dc.date.accessioned2025-01-21T16:43:44Z
dc.date.available2025-01-21T16:43:44Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, nanoparticles of amoxicillin (AMX) were prepared using chitosan (CHI) and polyethylene glycol (PEG). The physicochemical properties of the particles were investigated by FT-IR, DSC, SEM, and zeta potential analyses. The nanoparticles showed a spherical shape, and the average size of formulations was within the range of 696.20 +/- 24.86 - 359.53 +/- 7.41 nm. Zeta potential data demonstrated that the formulations had positive surface charges with a zeta potential range of 21.38 +/- 2.28 - 7.73 +/- 1.66 mV. FTIR analysis showed that the drug was successfully entrapped in the nanoparticles. DSC results suggested that the drug was present in amorphous form in the polymer matrix. In vitro release studies demonstrated that the release pattern consisted of two phases, with an initial burst release followed by a controlled and sustained release. The MTT assay results on mouse fibroblast cell line indicated that the prepared formulations did not affect the viability of the cells. In the in vitro antibacterial activity test, it was found that the drug-loaded nanoparticles have AMX-equivalent antibacterial activity against E. coli, and S. aureus. These findings revealed that the obtained nanoparticles might be a promising and safe nanocarrier system for efficient delivery of AMX.
dc.identifier.doi10.1080/09205063.2023.2179269
dc.identifier.endpage1682
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.issue12
dc.identifier.pmid36756763
dc.identifier.scopus2-s2.0-85148530915
dc.identifier.scopusqualityQ1
dc.identifier.startpage1660
dc.identifier.urihttps://doi.org/10.1080/09205063.2023.2179269
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25306
dc.identifier.volume34
dc.identifier.wosWOS:000937970400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Biomaterials Science-Polymer Edition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAmoxicillin; nanoparticles; chitosan; polyethylene glycol; antibacterial activity; cytotoxicity
dc.titlePreparation, characterization, and evaluation of antibacterial and cytotoxic activity of chitosan-polyethylene glycol nanoparticles loaded with amoxicillin as a novel drug delivery system
dc.typeArticle

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