Effect of electromagnetic fields and early postoperative 5-fluorouracil on the healing of colonic anastomoses

Basit Öğe Kaydı
dc.contributor.authorNayci, A.
dc.contributor.authorCakmak, M.
dc.contributor.authorRenda, N.
dc.contributor.authorAksoyek, S.
dc.contributor.authorYucesan, S.
dc.date.accessioned2020-06-25T17:35:34Z
dc.date.available2020-06-25T17:35:34Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.descriptionNayci, Ali/0000-0002-0534-1205
dc.description.abstractBackground and aims: Studies have indicated a deleterious effect of perioperative 5-fluorouracil (5-FU) administration on the healing of intestinal anastomoses. This study examined the effect of early postoperative 5-FU on the healing of colonic anastomoses and investigated the effect of electromagnetic fields (EMF) on colonic anastomotic repair under normal physiological conditions and in the presence of 5-FU therapy in a rat model. Materials and methods: Forty male Wistar rats were randomly assigned into four groups and underwent a standardized left colonic resection and anastomoses. The animals then served as control or received intraperitoneal 5-FU (20 mg/kg per day, 5 days), EMF stimulation (10.76 mT, 50 Hz; 2-h on/10-h off cycles, 7 days) or both, starting on the day of surgery. After 7 days anastomotic healing was assessed by measurement of hydroxyproline content and breaking strength. Results: Hydroxyproline content increased in EMF exposed group (1.53+/-0.11 to 1.92+/-0.11 mug/mg) and in EMF + 5-FU group (1.53+/-0.11 to 1.89+/-0.12 mug/mg). Breaking strength also increased in the EMF group (0.23+/-0.02 to 0.27+/-0.01 MPa) and in the EMF + 5-FU group (0.23+/-0.02 to 0.28+/-0.01 MPa. No differences were found in hydroxyproline content or breaking strength between the 5-FU group and controls. Conclusion: Early postoperative 5-FU administration did not impair the healing of colonic anastomoses in rats. Additionally, EMF stimulation provided a significant gain in colonic anastomotic strength, in rat intestines in control animals and in animals exposed to 5-FU.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00384-002-0454-z
dc.identifier.endpage141en_US
dc.identifier.issn0179-1958
dc.identifier.issue2en_US
dc.identifier.pmid12548416
dc.identifier.scopus2-s2.0-0038052180
dc.identifier.scopusqualityQ2
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.1007/s00384-002-0454-z
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3153
dc.identifier.volume18en_US
dc.identifier.wosWOS:000181357100008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofInternational Journal Of Colorectal Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectintestineen_US
dc.subjectanastomosesen_US
dc.subjectmagnetic fielden_US
dc.subject5-fluorouracilen_US
dc.subjectchemotherapyen_US
dc.subjectcolonen_US
dc.titleEffect of electromagnetic fields and early postoperative 5-fluorouracil on the healing of colonic anastomosesen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Effect of electromagnetic fields and early postoperative 5-fluorouracil on the healing of colonic anastomoses.pdf
Boyut:
182.5 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu