Expression of steroid receptors in intact rat uterus, mammary gland, and liver treated with selective estrogen receptor modulators and conjugated equine estrogens

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dc.contributor.authorBayram, Merih
dc.contributor.authorBayram, Orhan
dc.contributor.authorDursun, Ayşe
dc.contributor.authorIşık, İpek
dc.contributor.authorDileköz, Ergin
dc.contributor.authorÖzkan, Seçil
dc.date.accessioned2020-06-25T17:40:19Z
dc.date.available2020-06-25T17:40:19Z
dc.date.issued2005
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe aim of the present Study was to determine the effects of conjugated equine estrogens (CEE) and selective estrogen receptor modulators (SERM) (tamoxifen [TAM] and raloxifene [RALI) on the expression of steroid receptors-estrogen receptor (ER) and progesterone receptor (PR)-in intact rat uterus, mammary gland, and liver. A total of 24 female rats weighing 250 to 300 g were randomized into 4 groups. Groups 1, 2, 3, and 4 were respectively given conjugated equine estrogen, tamoxifen, raloxifene, and vehicle for a 28-day period. ER and PR expression was detected in tissues of the uterus, mammary gland, and liver. Uterine wet weight and serum estradiol levels were established for all groups. No statistical difference was observed between groups in the ER expression of mammary gland and liver and in the PR expression of uterus, mammary gland, and liver, but differences were noted in serum estradiol levels and uterine ER expression. Serum estradiol levels were lower in the TAM-treated group; differences between the TAM-treated group and the other groups were statistically important (P<.05). Uterine ER expression was greater in the CEE-treated group; differences between the CEE-treated group and the TAM- and RAL-treated groups were statistically important (P<.05). CEE or SERM versus vehicle treatment in controls did not seem to result in statistically important differences in ER and PR expression in intact rat uterus, mammary gland, and liver. Only ER expression in the uterus was found to be greater in the CEE-treated group than in SERM-treated groups.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/BF02849952
dc.identifier.endpage594en_US
dc.identifier.issn0741-238X
dc.identifier.issn1865-8652
dc.identifier.issue6en_US
dc.identifier.pmid16510375
dc.identifier.scopus2-s2.0-33645029236
dc.identifier.scopusqualityQ1
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.1007/BF02849952
dc.identifier.urihttps://hdl.handle.net/20.500.12587/3390
dc.identifier.volume22en_US
dc.identifier.wosWOS:000236068000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofAdvances In Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectconjugated equine estrogensen_US
dc.subjectCEEen_US
dc.subjectselective estrogen receptor modulatorsen_US
dc.subjectSERMen_US
dc.subjectestrogen receptor expressionen_US
dc.subjectprogesterone receptor expressionen_US
dc.titleExpression of steroid receptors in intact rat uterus, mammary gland, and liver treated with selective estrogen receptor modulators and conjugated equine estrogensen_US
dc.typeArticle

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