Preparation and Drug-Release Behavior of Minocycline-Loaded Poly[hydroxyethyl methacrylate-co-poly(ethylene glycol)-methacrylate] Films

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dc.contributor.authorBayramoğlu, Gülay
dc.contributor.authorBatislam, Ertan
dc.contributor.authorArıca, M. Yakup
dc.date.accessioned2020-06-25T17:48:28Z
dc.date.available2020-06-25T17:48:28Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractIn this work, biocompatible hydrogel matrices for wound-dressing materials and controlled drug-release systems were prepared from poly[hydroxyethyl methacrylate-co-poly(ethylene glycol)-methacrylate] [p(HEMA-co-PEG-MA] films via UV-initiated photopolymerization. The characterization of the hydrogels was conducted with swelling experiments, Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis (differential scanning calorimetry), and contact-angle studies. The water absorbency of the hydrogel films significantly changed with the change of the medium pH from 4.0 to 7.4. The thermal stability of the copolymer was lowered by an increase in the ratio of poly(ethylene glycol) (PEG) to methacrylate (MA) in the film structure. Contact-angle measurements on the surface of the p(HEMA-co-PEG-MA) films demonstrated that the copolymer gave rise to a significant hydrophilic surface in comparison with the homopolymer of 2-hydroxyethyl methacrylate (HEMA). The blood protein adsorption was significantly reduced on the surface of the copolymer hydrogels in comparison with the control homopolymer of HEMA. Model antibiotic (i.e., minocycline) release experiments were performed in physiological buffer saline solutions with a continuous flow release system. The amount of minocycline release was shown to be dependent on the HEMA/PEG-MA ratio. The hydrogels have good antifouling properties and therefore are suitable candidates for wound dressing and other tissue engineering applications. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 112:1012-1020, 2009en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/app.29450
dc.identifier.endpage1020en_US
dc.identifier.issn0021-8995
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-64249089959
dc.identifier.scopusqualityQ2
dc.identifier.startpage1012en_US
dc.identifier.urihttps://doi.org/10.1002/app.29450
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4462
dc.identifier.volume112en_US
dc.identifier.wosWOS:000263761100054
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherJohn Wiley & Sons Incen_US
dc.relation.ispartofJournal Of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiocompatibilityen_US
dc.subjectbiomaterialsen_US
dc.subjectdrug delivery systemsen_US
dc.subjectfilmsen_US
dc.subjecthydrophilic polymersen_US
dc.titlePreparation and Drug-Release Behavior of Minocycline-Loaded Poly[hydroxyethyl methacrylate-co-poly(ethylene glycol)-methacrylate] Filmsen_US
dc.typeArticle

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