The relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats

Basit Öğe Kaydı
dc.authoridUNLUKAL, NEJAT/0000-0002-8107-4882
dc.contributor.authorGoktepe, Emre
dc.contributor.authorBaltaci, Saltuk Bugra
dc.contributor.authorUnal, Omer
dc.contributor.authorUnlukal, Nejat
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.date.accessioned2025-01-21T16:55:13Z
dc.date.available2025-01-21T16:55:13Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: Zinc, which is found in high concentrations in the 13-cells of the pancreas, is also a critical component for the endocrine functions of the pancreas. SLC30A8/ZnT8 is the carrier protein responsible for the transport of zinc from the cytoplasm to the insulin granules. The aim of this study was to investigate how dietary zinc status affects pancreatic beta cell activation and ZnT8 levels in infant male rats born to zinc-deficient mothers.Methods: The study was performed on male pups born to mothers fed a zinc-deficient diet. A total of 40 male rats were divided into 4 equal groups. Group 1: In addition to maternal zinc deficiency, this group was fed a zinc -deficient diet. Group 2: In addition to maternal zinc deficiency, this group was fed a standard diet. Group 3: In addition to maternal zinc deficiency, this group was fed a standard diet and received additional zinc sup-plementation. Group 4: Control group. Pancreas ZnT8 levels were determined by ELISA method and insulin -positive cell ratios in 13-cells by immunohistochemistry.Results: The highest pancreatic ZnT8 levels and anti-insulin positive cell ratios in the current study were obtained in Group 3 and Group 4. In our study, the lowest pancreatic ZnT8 levels were obtained in Group 1 and Group 2, and the lowest pancreatic anti-insulin positive cell ratios were obtained in Group 1.Conclusion: The results of the present study; in rats fed a zinc-deficient diet after maternal zinc deficiency has been established shows that ZnT8 levels and anti-insulin positive cell ratios in pancreatic tissue, which is significantly suppressed, reach control values with intraperitoneal zinc supplementation.
dc.description.sponsorshipScientific Research Projects Coor- dinatorship of Selcuk University [20202011]
dc.description.sponsorshipFunding This study was supported by the Scientific Research Projects Coor- dinatorship of Selcuk University (SUBAPK; project no. 20202011) .
dc.identifier.doi10.1016/j.jtemb.2023.127217
dc.identifier.issn0946-672X
dc.identifier.issn1878-3252
dc.identifier.pmid37224745
dc.identifier.scopus2-s2.0-85159801837
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2023.127217
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25728
dc.identifier.volume79
dc.identifier.wosWOS:001010814200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofJournal of Trace Elements In Medicine and Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectMaternal zinc deficiency; Zinc; Pancreas; ZnT8
dc.titleThe relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu