Is subclinical hypothyroidism contributing dyslipidemia and insulin resistance in women with polycystic ovary syndrome?

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dc.contributor.authorÇelik, Cem
dc.contributor.authorAbalı, Remzi
dc.contributor.authorTaşdemir, Nicel
dc.contributor.authorGüzel, Savaş
dc.contributor.authorYüksel, Aytaç
dc.contributor.authorAksu, Erson
dc.contributor.authorYılmaz, Murat
dc.date.accessioned2020-06-25T18:06:32Z
dc.date.available2020-06-25T18:06:32Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe aimed to analyze lipid parameters and determine the need for a 2-hour oral glucose tolerance test (OGTT) for the identification of IR and impaired glucose tolerance test (IGT) in subclinical hypothyroidism (SCH) women with and without polycystic ovary syndrome (PCOS). 20 patients with PCOS and SCH consisted of Group I and 39 patients with PCOS and normal thyroid function consisted of Group II and 53 healthy women with normal thyroid function consisted of Group III. Triglyceride levels were 143.26 +/- 99.86 mg/dL in group 1 and 88.56 +/- 37.56 mg/dL in group 2 and 83.71 +/- 31.94 mg/dL in group 3 which were statistically significant. Total cholesterol, HDL-cholesterol, LDL-cholesterol were found similar between the groups. Fasting insulin levels were 12.45 +/- 8.62 mu U/mL in group 1 and 8.60 +/- 5.35 mu U/mL in group 2 and 7.04 +/- 3.55 mu U/mL in group 3 which were statistically significant (P = 0.027). HOMA-IR were 2.92 +/- 2.34 in group 1 and 1.95 +/- 1.52 in group 2 and 1.60 +/- 0.86 in group 3 which were statistically significant (P = 0.046). This study showed that women with PCOS and subclinical hypothyroidism should be evaluated for dyslipidemia and Insulin resistance.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/09513590.2011.650765
dc.identifier.endpage618en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue8en_US
dc.identifier.pmid22329744
dc.identifier.startpage615en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2011.650765
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5229
dc.identifier.volume28en_US
dc.identifier.wosWOS:000306427700010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypothyroidismen_US
dc.subjectinsulin resistanceen_US
dc.subjectpolycystic ovary syndromeen_US
dc.titleIs subclinical hypothyroidism contributing dyslipidemia and insulin resistance in women with polycystic ovary syndrome?en_US
dc.typeArticle

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