Investigation of the Genotoxic Effect of Fluoxetine Hydrochloride in Drosophila melanogaster

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dc.authoridÖz, Selda/0000-0003-1883-3441
dc.contributor.authorÖz, Selda
dc.contributor.authorSarıkaya, Zeynep Nur
dc.contributor.authorLarçin, Özüm
dc.contributor.authorSarıkaya, Rabia
dc.date.accessioned2025-01-21T16:33:57Z
dc.date.available2025-01-21T16:33:57Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study aimed to determine the potential genotoxic effect of fluoxetine hydrochloride (FLX-HCl), an antidepressant commonly used for treating depression, using Somatic Mutation and Recombination Test (SMART). Third-instar Drosophila melanogaster larvae transheterozygous for the mutations multiple wing hair (mwh) and flare (flr3) were chronically fed in a medium containing different concentrations of FLX-HCl (0.1, 0.5, 1, and 2 mg/mL) in the experimental group. Distilled water, 0.1 mM ethyl methane sulfonate (EMS), and 2% dimethyl sulfoxide (DMSO) were used in negative, positive, and solvent control groups, respectively. The survival percentages were calculated by determining the number of individuals surviving when the larvae completed their development in the experimental and control groups. In all application groups, the wings of 40 individuals with both normal and serrate wing phenotypes were examined under a microscope, and genetic changes were evaluated by counting the mutant clones in the wings. The data obtained show that 1 and 2 mg/mL concentrations of FLX-HCl caused toxic effects in D. melanogaster individuals. Additionally, FLX-HCl showed a negative genotoxic effect at 0.1 mg/mL concentration, insignificant at 0.5 mg/mL concentration, and positive at 1 and 2 mg/mL concentrations in terms of total mutation evaluation and clone induction frequency in D. melanogaster individuals.
dc.identifier.doi10.18016/ksutarimdoga.vi.1310729
dc.identifier.endpage324
dc.identifier.issn2619-9149
dc.identifier.issue2
dc.identifier.startpage316
dc.identifier.trdizinid1249444
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.1310729
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1249444
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23887
dc.identifier.volume27
dc.identifier.wosWOS:001196996600016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherKahramanmaras Sutcu Imam Univ Rektorlugu
dc.relation.ispartofKsu Tarim Ve Doga Dergisi-Ksu Journal of Agriculture and Nature
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectDrosophila melanogaster; Fluoxetine hydrochloride; Genotoxicity; Survival; SMART
dc.titleInvestigation of the Genotoxic Effect of Fluoxetine Hydrochloride in Drosophila melanogaster
dc.typeArticle

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