Development of chitosan-graphene oxide blend nanoparticles for controlled flurbiprofen delivery

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dc.contributor.authorErol, Umit Haydar
dc.contributor.authorGuncum, Enes
dc.contributor.authorIsiklan, Nuran
dc.date.accessioned2025-01-21T16:37:33Z
dc.date.available2025-01-21T16:37:33Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe use of natural polymeric nanoparticles (Nps) as drug carriers is a highly promising area of research in the field of drug delivery systems because of their high efficiency. In this study, flurbiprofen (FB) loaded chitosangraphene oxide (CS-GO) blend Nps were synthesized as a controlled delivery system using the emulsion method. The crystalline, molecular, and morphological structures of the prepared CS-GO Nps were characterized using a variety of analytical methods, including Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-Ray diffractometry (XRD), scanning electron microscopy (SEM), and atomic force microscopy (AFM). It was found that the introduction of GO into the CS nanoparticle formulation increased its thermal stability. The range of the average particle size was between 362 & PLUSMN; 5.06 and 718 & PLUSMN; 2.21 nm, with negative zeta potential values between -7.67 & PLUSMN; 4.16 and - 27.93 & PLUSMN; 2.26 mV. The effects of the CS/GO ratio, the FB/polymer ratio, the amount of span 80, and the cross-linker concentration were assessed on FB release profiles. In vitro release studies displayed a two-stage release behaviour with a fast initial release of the FB, followed by sustained and extended release, and the incorporation of GO into the CS Nps made the FB release more sustained and controlled manner. Besides, the cytotoxicity test of the FB-loaded CS-GO Nps was studied through MTT assay, and it was found that they were biocompatible. Based on these findings, it can be inferred that the prepared CS-GO Nps might be a promising candidate drug carrier system for FB.
dc.description.sponsorshipKirikkale University's Scien-tific Research Projects Coordination Unit [2014/39]
dc.description.sponsorshipThe authors express their gratitude to Kirikkale University's Scien-tific Research Projects Coordination Unit for providing financial assis-tance under project number 2014/39.
dc.identifier.doi10.1016/j.ijbiomac.2023.125627
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid37406912
dc.identifier.scopus2-s2.0-85164227829
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.125627
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24499
dc.identifier.volume246
dc.identifier.wosWOS:001037460900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectChitosan; Graphene oxide; Blend nanoparticles; Drug delivery; Flurbiprofen
dc.titleDevelopment of chitosan-graphene oxide blend nanoparticles for controlled flurbiprofen delivery
dc.typeArticle

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