Differences in autonomic activity in individuals with optimal, normal, and high-normal blood pressure levels

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dc.authoridÖzer, Nurtaç/0000-0001-7533-8784
dc.contributor.authorDogru, M. Tolga
dc.contributor.authorŞimşek, Vedat
dc.contributor.authorŞahin, Ömer
dc.contributor.authorÖzer, Nurtaç
dc.date.accessioned2025-01-21T16:33:17Z
dc.date.available2025-01-21T16:33:17Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: We investigated differences in autonomic activity in normotensive individuals having optimal, normal and high-normal blood pressure (BP) levels according to the guidelines of the European Society of Hypertension and European Society of Cardiology (ESH/ESC). Study design: The study included 294 normotensive subjects (135 males, 159 females; age range 16 to 75 years) with similar clinical, morphometric, biochemical, electrocardiographic, and echocardiographic features. The subjects were classified into the following BP groups: group 1 (n=113) with optimal BP (<120/80 mmHg); group 2 (n=104) with normal BP (120-129/80-84 mmHg), and group 3 (n=77) with high-normal BP (130-139/85-89 mmHg). All the subjects underwent 24-hour Holter monitoring to obtain heart rate variability (HRV) parameters of 24-hour, daytime, and nighttime periods. Normalized low (LFn) and high (HFn) frequency powers, and logarithmic (Log) values of HRV parameters were also calculated. Results: On 24-hour Holter monitoring, heart rates were similar in three groups. Compared to group 1 and 2, group 3 exhibited significantly higher LF/HF (p<0.001) and LFn (p=0.001) values, and significantly lower HFn (p=0.001), pNN50 (p=0.001), and rMSSD (p=0.005) values. There were no significant differences between the groups with respect to daytime HRV parameters; however, nighttime LF/HF, LFn, and HFn values were significantly different between the groups. Log LF/HF values obtained during the 24-hour and nighttime periods showed significant differences between group 1 and group 3 (for 24 hours, p<0.001; for night, p=0.001) and between group 2 and group 3 (for 24 hours, p<0.001; for night, p=0.009), but group 1 and group 2 did not differ significantly in this respect (p>0.05). Conclusion: These findings suggest that subjects with high-normal BP have increased sympathetic activity and decreased parasympathetic activity, possibly making them more liable to hypertension.
dc.identifier.endpage188
dc.identifier.issn1016-5169
dc.identifier.issn1308-4488
dc.identifier.issue3
dc.identifier.pmid20675995
dc.identifier.scopusqualityQ3
dc.identifier.startpage182
dc.identifier.trdizinid113903
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay113903
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23775
dc.identifier.volume38
dc.identifier.wosWOS:000421496600004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAutonomic nervous system; blood pressure; electrocardiography; ambulatory; heart rate; hypertension
dc.titleDifferences in autonomic activity in individuals with optimal, normal, and high-normal blood pressure levels
dc.typeArticle

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